Glycosylation

Glycosylation is the process or result of addition of saccharides to proteins and lipids. The process is one of four principal co-translational and post-translational modification steps in the synthesis of membrane and secreted proteins and the majority of proteins synthesized in the rough ER undergo glycosylation. It is an enzyme-directed site-specific process, as opposed to the non-enzymatic chemical reaction of glycation. Two types of glycosylation exist: N-linked glycosylation to the amide nitrogen of asparagine side chains and O-linked glycosylation to the hydroxy oxygen of serine and threonine side chains. (From the Wikpedia article Glycosylation.)

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Recent Publications on Glycosylation:
Conformational Effects of the Non-natural alpha-Methylserine on Small Peptides and Glycopeptides. The synthesis and the conformational analysis in aqueous solution of a...	21st November, 2009	Departamento de Quimica, Universidad de La Rioja, Centro de Investigacion	J Org Chem. 2009 Nov 19. DOI Direct Link
A novel epimerase that converts GlcNAc-P-P-undecaprenol to GalNAc-P-P-undecaprenol in E. coli O157. E. coli strain O157 produces an O-antigen with the repeating...	20th November, 2009	University of Kentucky college of Med., United States;	J Biol Chem. 2009 Nov 18. DOI Direct Link
NTPDase family in zebrafish: Nucleotide hydrolysis, molecular identification and gene expression profiles in brain, liver and heart. The nucleoside triphosphate diphosphohydrolase (NTPDase) family cleaves...	20th November, 2009	Programa de Pos-graduacao em Bioquimica, Departamento de Bioquimica,	Comp Biochem Physiol B Biochem Mol Biol. 2009 Nov 13. DOI Direct Link
Production and N-glycosylation of recombinant human cell adhesion molecule L1 from insect cells using the stable expression system. Effect of dimethyl sulfoxide. L1 is a cell adhesion molecule that is heavily glycosylated and is...	20th November, 2009	Instituto de Tecnologia Quimica e Biologica, Avenida da Republica,	J Biotechnol. 2009 Nov 13. DOI Direct Link
Tandem 18O Stable Isotope Labeling for Quantification of N-glycoproteome. A new strategy using tandem 18O stable isotope labeling (TOSIL)...	20th November, 2009		J Proteome Res. 2009 Nov 19. DOI Direct Link
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Press Releases About Glycosylation:
Reportlinker Adds Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment	26th October, 2009	Reportlinker	-- A focus on "engineered" antibodies Monoclonal Antibodies: Pipeline Analysis and Competitive Assessment reviews the broad drug development effort that is focused on bringing
Sigma-Aldrich and Procognia Enter Exclusive Partnership for	1st November, 2004	Sigma Aldrich	Sigma-Aldrich and Procognia Enter Exclusive Partnership for Commercialization of Functional Human Protein Arrays St Louis, MO and Taufkirchen, Germany, 9th November 2004 – Sigma-Aldrich

BioNews Results for Glycosylation:
ZyStor Therapeutics, Inc. Cleared to Begin Clinical Trial for Targeted Protein Therapeutic for the Treatment o	Pharma Live:  Oct 18 2009 3:17AM Matching: glycosylation
ZyStor Therapeutics, Inc. Cleared To Begin Clinical Trial For Targeted Protein Therapeutic For The Treatment O	Medical News Today:  Oct 15 2009 2:02PM Matching: glycosylation
ZyStor Therapeutics, Inc. Cleared to Begin Clinical Trial for Targeted Protein Therapeutic for the Treatment of Pompe Disease	Montana's News Station:  Oct 15 2009 5:06AM Matching: glycosylation
ZyStor Therapeutics, Inc. Cleared to Begin Clinical Trial for Targeted Protein Therapeutic for the Treatment o	Pharmacy Choice:  Oct 15 2009 12:02AM Matching: glycosylation
Medical News: ZyStor Therapeutics, Inc. Cleared To Begin Clinical Trial For Targeted Protein Therapeutic For The Treatment Of Pompe Disease	Medical News Today:  Oct 15 2009 1:50PM Matching: glycosylation
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Glycosylation Patents:
US Patent No.	Title
7615225	Methods for treating a subject having cancer by the administration of a conjugate between a variant staphylococcal entertoxin E superantigen and an antibody that binds to the 5T4 antigen
7615613	Antigen constructs useful in the detection and differentiation of antibodies to HIV
7615614	Antigen constructs useful in the detection and differentiation of antibodies to HIV
7615622	Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor VIII
7615639	1-pyridyl-benzofuro[3,2-b]pyridin-2(1H)-ones
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Companies working in the area of Glycosylation from Bioportfolio's Biocorporate database :
Company Name
Alteon Incorporated Alteon is engaged in the discovery and development of pharmaceutical products for the treatment of the complications of diabetes and age-related diseases. Alteon's efforts have focused primarily on... www.alteon.com/        View full profile
Biocept Incorporated Privately held Biocept was founded in 1997 and is based in Carlsbad, California near San Diego. Biocept is emerging as a leader in the development and commercialization, in part through... www.biocept.com/        View full profile
Xerion Pharmaceuticals GmbH Xerion's proprietary protein/ligand identification technology platform, Xcelerate, focuses on the combination of proteome-wide protein separation from any biological source, high-throughput protein... www.xerion-pharma.com/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Glycosylation scientists - we have details of around 3179 individuals working on Glycosylation .