Halogenation

Halogenation is a chemical reaction that incorporates a halogen atom into a molecule. More specific descriptions exist that specify the type of halogen: fluorination, chlorination, bromination, and iodination.In a Markovnikov addition reaction, a halogen like bromine is reacted with an alkene which causes the π-bond to break forming an haloalkane. This makes the hydrocarbon more reactive and bromine as it turns out, is a good leaving group in further chemical reactions such as nucleophilic aliphatic substitution reactions and elimination reactionsSeveral main types of halogenation exist, including:* Free radical halogenation* Ketone halogenation* Electrophilic halogenation* Halogen addition reactionSpecific halogenation methods are the Hunsdiecker reaction and the Sandmeyer reaction .An example of halogenation can be found in the organic synthesis of the anesthetic halothane from trichloroethylene which involves a high temperature bromination in the second step : (From the Wikpedia article Halogenation.)

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Recent Publications on Halogenation:
Real-time detection and identification of aqueous chlorine transformation products using QTOF MS. A screening technique has been developed that allows the rapid, real-time...	19th July, 2008	Southern Nevada Water Authority, P.O. Box 99954, Las Vegas, Nevada	Anal Chem. 2008 Jun 1;80(11):4193-9. Epub 2008 May 9. DOI Direct Link
Iodinated salicylate-based poly(anhydride-esters) as radiopaque biomaterials. Poly(anhydride-esters) based on iodinated versions of salicylic acid were...	17th July, 2008	Department of Chemistry and Chemical Biology, Rutgers University,	Biomacromolecules. 2008 Jun;9(6):1604-12. Epub 2008 May 16. DOI Direct Link
Cinchona alkaloid catalyzed enantioselective fluorination of allyl silanes, silyl enol ethers, and oxindoles. 5''-Iodinated oligodeoxyribonucleotides readily react with...	17th July, 2008	Department of Applied Chemistry, Graduate School of Engineering, Nagoya	Angew Chem Int Ed Engl. 2008;47(22):4157-61. DOI Direct Link
Fluorinated photoremovable protecting groups: the influence of fluoro substituents on the photo-Favorskii rearrangement. To further explore the nature of the photo-Favorskii rearrangement and its...	10th July, 2008	Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive,	Photochem Photobiol Sci. 2008 May;7(5):614-24. Epub 2008 Apr 3. DOI Direct Link
Influence of substitution, hybridization, and solvent on the properties of C-HO single-electron hydrogen bond in CH3-H2O complex. The effect of substitution, hybridization, and solvent on the properties...	8th July, 2008	Science and Engineering College of Chemistry and Biology, Yantai	J Phys Chem A. 2008 Jun 12;112(23):5258-63. Epub 2008 May 15. DOI Direct Link
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BioNews Results for Halogenation:
Jubilant acquires Speciality Molecules to strengthen Pyridine portfolio	PharmaBiz:  May 9 2008 12:42PM Matching: halogenation

Halogenation Patents:
US Patent No.	Title
7371793	Nanocomposite comprising stabilization functionalized thermoplastic polyolefins
7378456	Directly photodefinable polymer compositions and methods thereof
7378470	Molding compositions based on a thermoplastic polyester with improved flowability
7378482	Compositions having improved bath life
7378518	Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
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Companies working in the area of Halogenation from Bioportfolio's Biocorporate database :
Company Name
Orgamol SA Orgamol S.A. is an incorporated, privately-owned and independent Swiss manufacturer of fine chemicals, active pharmaceutical ingredients (APIs), advanced pharmaceutical intermediates and generics.... www.orgamol.com/        View full profile

BioPortfolio Ltd. offers e-mail and postal lists for Halogenation scientists - we have details of around 45 individuals working on Halogenation .

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