Halogenation

Halogenation is a chemical reaction that incorporates a halogen atom into a molecule. More specific descriptions exist that specify the type of halogen: fluorination, chlorination, bromination, and iodination.In a Markovnikov addition reaction, a halogen like bromine is reacted with an alkene which causes the π-bond to break forming an haloalkane. This makes the hydrocarbon more reactive and bromine as it turns out, is a good leaving group in further chemical reactions such as nucleophilic aliphatic substitution reactions and elimination reactionsSeveral main types of halogenation exist, including:* Free radical halogenation* Ketone halogenation* Electrophilic halogenation* Halogen addition reactionSpecific halogenation methods are the Hunsdiecker reaction and the Sandmeyer reaction .An example of halogenation can be found in the organic synthesis of the anesthetic halothane from trichloroethylene which involves a high temperature bromination in the second step : (From the Wikpedia article Halogenation.)

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Recent Publications on Halogenation:
Knockdown of the type 3 iodothyronine deiodinase (D3) interacting protein peroxiredoxin 3 decreases D3-mediated deiodination in intact cells. The type 3 iodothyronine deiodinase (D3) is the primary deiodinase that...	17th November, 2009	Thyroid Section, Division of Endocrinology, Diabetes, and Hypertension,	Endocrinology. 2009 Nov;150(11):5171-80. Epub 2009 Oct 9. DOI Direct Link
First-principles study of non-heme Fe(II) halogenase SyrB2 reactivity. We present here a computational study of reactions at a model complex of...	17th November, 2009	Department of Materials Science & Engineering, Massachusetts Institute of	J Am Chem Soc. 2009 Oct 14;131(40):14426-33. DOI Direct Link
Umpolung of halide reactivity: efficient (diacetoxyiodo)benzene-mediated electrophilic alpha-halogenation of 1,3-dicarbonyl compounds. An efficient high-yielding (diacetoxyiodo)benzene-mediated...	12th November, 2009	Centre for Synthesis and Chemical Biology, School of Chemistry and	Chem Commun (Camb). 2009 Dec 7;(45):6991-3. Epub 2009 Oct 12. DOI Direct Link
Tetraalkylphosphonium Trihalides. Room Temperature Ionic Liquids As Halogenation Reagents. Six room temperature ionic liquids (RTILs) comprised of a...	10th November, 2009	Department of Chemistry, Georgetown University, Washington, D.C.	J Org Chem. 2009 Nov 6. DOI Direct Link
Application of electrolysis to stimulate microbial reductive PCE dechlorination and oxidative VC biodegradation. A novel approach was applied to stimulate biodegradation of chloroethenes...	7th November, 2009	Water Technology Center, Department of Environmental Biotechnology,	Environ Sci Technol. 2009 Sep 15;43(18):7098-104.
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Halogenation Patents:
US Patent No.	Title
7598372	Synthesis of core sugar chain structure of asparagine-linked glycoprotein
7604920	Positive resist composition, method of forming resist pattern, polymeric compound, and compound
7605134	4''-Deoxy-4''-(s)-amino avermectin derivatives
7605144	Enzyme catalyzed therapeutic compounds
7605175	Inhibitors of cyclin-dependent kinases, compositions and uses related thereto
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Companies working in the area of Halogenation from Bioportfolio's Biocorporate database :
Company Name
Orgamol SA Orgamol S.A. is an incorporated, privately-owned and independent Swiss manufacturer of fine chemicals, active pharmaceutical ingredients (APIs), advanced pharmaceutical intermediates and generics.... www.orgamol.com/        View full profile

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