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Hamartoma

A hamartoma is a focal malformation that resembles a neoplasm in the tissue of its origin. This is not a malignant tumor, and it grows at the same rate as the surrounding tissues. It is composed of tissue elements normally found at that site, but which are growing in a disorganized mass. They occur in many different parts of the body and are most often asymptomatic and undetected unless seen on an image taken for another reason. Hamartomas result from an abnormal formation of normal tissue, although the underlying reasons for the abnormality are not fully understood. They grow along with, and at the same rate as, the organ from whose tissue they are made, and, unlike cancerous tumors, only rarely invade or compress surrounding structures significantly.Hamartomas, while generally benign, can cause problems due to their location. When located on the skin, especially the face or neck, they can be extremely disfiguring, as in the case of a man with a hamartoma the size of a small orange on his eyelid. They may obstruct practically any organ in the body, such as the eye, the colon, etc. They are particularly likely to cause major health issues when located in the hypothalamus, spleen or kidneys. (From the Wikpedia article Hamartoma.)

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Recent Publications on Hamartoma:

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Porokeratotic eccrine ostial and dermal duct naevus: report of 10 cases.
Abstract Background Porokeratotic eccrine ostial and dermal duct nevus...
21st November, 2009
Department of Dermatology, Hospital Sant Joan de Deu, University of J Eur Acad Dermatol Venereol. 2009 Nov 18.
DOI Direct Link
Respiratory epithelial adenomatoid hamartoma of the anterior nasal septum a rare localisation of an unusual tumour in a child: a case report.
INTRODUCTION: Hamartomas are non-neoplastic lesions constituted by a...
18th November, 2009
Cases J. 2009 Sep 16;2:8151.
DOI Direct Link
Tailgut cyst, an unusual cause of pseudomyxoma peritonei.
BACKGROUND: Retrorectal hamartoma, also known as tailgut cyst, is a rare...
18th November, 2009
Washington Cancer Institute, Washington, DC 20010, USA. Tumori. 2009 Jul-Aug;95(4):514-7.
Respiratory epithelial adenomatoid hamartoma in a dog.
A 6-month-old, intact, male Weimaraner dog presented to the veterinary...
11th November, 2009
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland J Vet Diagn Invest. 2009 Nov;21(6):918-20.
[Mesenchymal hamartoma of the liver in an elderly man.]
The mesenchymal hamartoma of the liver is a non frequent benign tumor with...
10th November, 2009
Departamento de Cirugia General, Instituto de Investigaciones Medicas Medicina (B Aires). 2009;69(5):554-6.

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Hamartoma Patents:

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US Patent No.Title
7504413 N-(4-(imidazo[1,2A]pyridin-YL)phenethyl)benzamide inhibitors of the mitotic kinesin CENP-E for treating certain cellular proliferation diseases
7544695 Spirocyclic compounds
7547724 IAP BIR domain binding compounds
7547766 Anti-tango294 antibodies and uses thereof
7547804 Compounds, compositions, and methods employing same

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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