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Hamartoma

A hamartoma is a focal malformation that resembles a neoplasm in the tissue of its origin. This is not a malignant tumor, and it grows at the same rate as the surrounding tissues. It is composed of tissue elements normally found at that site, but which are growing in a disorganized mass. They occur in many different parts of the body and are most often asymptomatic and undetected unless seen on an image taken for another reason. Hamartomas result from an abnormal formation of normal tissue, although the underlying reasons for the abnormality are not fully understood. They grow along with, and at the same rate as, the organ from whose tissue they are made, and, unlike cancerous tumors, only rarely invade or compress surrounding structures significantly.Hamartomas, while generally benign, can cause problems due to their location. When located on the skin, especially the face or neck, they can be extremely disfiguring, as in the case of a man with a hamartoma the size of a small orange on his eyelid. They may obstruct practically any organ in the body, such as the eye, the colon, etc. They are particularly likely to cause major health issues when located in the hypothalamus, spleen or kidneys. (From the Wikpedia article Hamartoma.)

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Recent Publications on Hamartoma:

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Androgen receptor overexpression in Becker nevus: histopathologic and immunohistochemical analysis.
Background: Becker nevus (BN) is a unilateral, hairy, pigmented cutaneous...
12th July, 2008
Department of Dermatology, Ajou University School of Medicine, Suwon, J Cutan Pathol. 2008 Jun 18;.
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Videothoracoscopic excision of mediastinal tumors and cysts using the harmonic scalpel.
OBJECTIVE: The aim of this study was to evaluate the safety and...
11th July, 2008
Department of Thoracic Surgery, Guy's Hospital, London, United Kingdom. Thorac Cardiovasc Surg. 2008 Aug;56(5):278-82.
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Lipofibromatous hamartoma of the median nerve in patients with macrodactyly: diagnosis and treatment of a rare disease causing carpal tunnel syndrome.
Lipofibromatous hamartoma is a very rare benign peripheral nerve tumour....
11th July, 2008
Department of Plastic Surgery, Hand Surgery, Burn Unit, University Arch Orthop Trauma Surg. 2008 Jul 10;.
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Resection of a endobronchial hamartoma by electrocautery and argon plasma ablation via fiberoptic bronchoscopy.
Endobronchial hamartoma is a rare benign tumour of the lung that may...
10th July, 2008
Department of Chest Medicine, P D Hinduja National Hospital and Research Indian J Chest Dis Allied Sci. 2006 Jul-Sep;48(3):217-9.
Giant leiomyomatous hamartoma of the tongue.
BACKGROUND: A male infant was born with a digit attached to a skin-covered...
8th July, 2008
School of Nursing, University Presidente Antonio Carlos, Uberaba, Brazil. J Oral Maxillofac Surg. 2008 Jul;66(7):1476-80.
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BioNews Results for Hamartoma:

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N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas
Nature:  Jul 11 2008 2:57PM Matching: hamartoma
Report summarizes epilepsy study findings from P. Romanelli and co-researchers
Therapeutics Daily:  Jul 10 2008 7:19PM Matching: hamartoma
Use of biomolecular targets in the treatment and visualization of tumors
PharmCast:  May 22 2008 3:52AM Matching: hamartoma

Hamartoma Clinical Trials:

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Phenotype and Etiology of Pallister-Hall Syndrome
Malformations;   Multiple Abnormalies;   Polydactyly
Study of Skin Tumors in Tuberous Sclerosis
Hereditary Neoplastic Syndrome;   Tuberous Sclerosis
Study of the Disease Process of Lymphangioleiomyomatosis
Lung Disease;   Pneumothorax;   Tuberous Sclerosis
RAD001 Therapy of Angiomyolipomata in Patients With TS Complex and Sporadic LAM
Tuberous Sclerosis;   Lymphangioleiomyomatosis
Tuberous Sclerosis Complex Natural History Study: Renal Manifestations
Tuberous Sclerosis Complex

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Hamartoma Patents:

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US Patent No.Title
7226592 Bispecific anti-Erb-B antibodies and their use in tumor therapy
7262187 Substituted oxazolo- and thizaolopyrimidinones as a mitotic kinesin inhibitor
7262288 Nucleic acids encoding human telomerase reverse transcriptase and related homologs
7271167 Compounds, compositions, and methods
7274810 System and method for three-dimensional image rendering and analysis

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BioPortfolio Ltd. offers e-mail and postal lists for Hamartoma scientists - we have details of around 689 individuals working on Hamartoma .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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