Hemangioma

A hemangioma is an abnormal build up of blood vessels in the skin or internal organs. It is also described as a congenital benign skin lesion consisting of dense, usually elevated masses of dilated blood vessels". In most cases, hemangiomas will disappear over time. They are formed either during gestation or appear during the first few weeks of life and may present as a birthmark. Hemangiomas are the most common childhood tumor occurring in approximately ten percent of Caucasians, and are less prevalent in other races. Females are three to five times more likely to have hemangiomas than males. Hemangiomas can be vivid superficial lesions, known as capillary hemangiomas , or they can be deep bluish swelling, known as cavernous hemangiomas. Sometimes they can be both superficial and deep. Approximately eighty percent are located on the face and neck, with the next most prevalent location being the liver. Although hemangiomas are benign, some serious complications can occur. The cause of hemangioma is currently unknown; however, several studies have suggested the importance of estrogen signaling in hemangioma proliferation. In 2007, a paper from the Stanford Children's Surgical Laboratory revealed that localized soft tissue hypoxia coupled with increased circulating estrogen after birth may be the stimulus. There is also a hypothesis presented by researchers at Harvard and the University of Arkansas that maternal placenta embolizes to the fetal dermis during gestation resulting in hemangiomagenesis, yet Duke researchers conducted genetic analyses of small nucleotide polymorphisms in hemangioma tissue compared to the mother's DNA that contradicted this notion. More research is required in order to fully understand the explosive nature of hemangioma growth which will hopefully yield targeted therapeutics to treat its most complicated presentations. (From the Wikpedia article Hemangioma.)

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Recent Publications on Hemangioma:
Maternal Lyme borreliosis and pregnancy outcome. BACKGROUND: There is disagreement regarding whether Lyme borreliosis is...	21st November, 2009	The Center for Tick-borne Diseases, Visegradi 14, Budapest, H-1132,	Int J Infect Dis. 2009 Nov 17. DOI Direct Link
Superimposed Segmental Hemangioma of Infancy. Background: Segmental hemangioma of infancy is sometimes associated with...	20th November, 2009	Department of Dermatology, University Medical Center Freiburg, Freiburg,	Dermatology. 2009 Nov 17. DOI Direct Link
[Scintigraphic diagnosis of an intramuscular hemangioma of the sternocleidomastoid muscle.] Background: Segmental hemangioma of infancy is sometimes associated with...	20th November, 2009	Servico de Medicina Nuclear, Hospital Sao Joao, Porto, Portugal.	Rev Esp Med Nucl. 2009 July - August;28(4):204-206. Epub 2009 Jul 8. DOI Direct Link
Skin metastasis: a pathologist's perspective. Skin metastasis is defined as the spread of malignant cells from a primary...	20th November, 2009	Department of Pathology, Assir Central Hospital, Kingdom of Saudi Arabia.	J Cutan Pathol. 2009 Nov 17. DOI Direct Link
Atypical lymphoid proliferation in capillary hemangioma: a finding related to bacterial infection? Skin metastasis is defined as the spread of malignant cells from a primary...	20th November, 2009	Department of Anatomic Pathology, University of Modena and Reggio Emilia,	J Cutan Pathol. 2009 Nov 17. DOI Direct Link
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BioNews Results for Hemangioma:
Propranolol treatment for infantile hemangiomas	MDLinx:  Nov 13 2009 11:06AM Matching: hemangioma
WCE suitable for detecting small intestinal pathology in young children	MedWire News:  Nov 4 2009 5:37AM Matching: hemangioma
High Dose Iodine 125 Episcleral Brachytherapy for Circumscribed Choroidal Hemangioma.	British Journal of Ophthalmology:  Oct 14 2009 11:26PM Matching: hemangioma
High Dose Iodine 125 Episcleral Brachytherapy for Circumscribed Choroidal Hemangioma. [Clinical Science]	British Journal of Ophthalmology:  Oct 13 2009 4:09AM Matching: hemangioma
Round table: Vision screenings vs. mandatory exams, MRI vs. CT	PCON SuperSite:  Oct 13 2009 12:49PM Matching: hemangioma
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Hemangioma Patents:
US Patent No.	Title
7576209	Inhibitors of Akt activity
7588760	Antagonists specific for denatured collagen and methods of using same
7588898	Biomarker for gestational trophoblastic disease
7589057	Oil-in-water method for making alpha-2 agonist polymeric drug delivery systems
7589068	Inhibitors of Akt activity
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