Histocompatibility

Histocompatibility is the property of having the same, or mostly the same, alleles of a set of genes called the major histocompatibility complex. These genes are expressed in most tissues as antigens, to which the immune system makes antibodies. The immune system at first makes antibodies to all sorts of antigens, including those it has never been exposed to, but stops making them to antigens present in the body. If the body is exposed to foreign antigens, as by getting a tissue graft, it attacks the foreign material unless it is histocompatible.A similar system exists in many plants; its purpose is not to reject grafts, but to prevent inbreeding. Pollen from a plant sharing a histocompatibility gene with the female either fails to grow or dies soon after germinating. (From the Wikpedia article Histocompatibility.)

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Recent Publications on Histocompatibility:
Interleukin-15 Receptor Blockade in Non-Human Primate Kidney Transplantation. BACKGROUND.: Interleukin (IL)-15 is a chemotactic factor to T cells. It...	6th February, 2010	1Division of Transplantation, Department of Surgery, Clinical Science	Transplantation. 2010 Feb 3. DOI Direct Link
Interleukin-2 inhibits polarization to T helper type 1 cells and prevents mouse acute graft-versus-host disease through up-regulating suppressors of cytokine signalling-3 expression of naive CD4 T cells. Summary T helper type 1 (Th1)-type polarization plays a critical role in...	6th February, 2010	Department of Haematology, Huashan Hospital, Shanghai Medical College,	Clin Exp Immunol. 2010 Feb 2. DOI Direct Link
Effect of renal and non-renal ischemia/reperfusion on cell-mediated immunity in organs and plasma. Brochner AC, Dagnaes-Hansen F, Toft P. Effect of renal and non-renal...	6th February, 2010	Department of Anesthesiology and Intensive Care Medicine, Odense	APMIS. 2010 Feb;118(2):101-107. DOI Direct Link
The N-Glycanase png-1 Acts to Limit Axon Branching during Organ Formation in Caenorhabditis elegans. Peptide:N-glycanases (PNGases) are cytoplasmic de-N-glycosylation enzymes...	5th February, 2010	Ottawa Health Research Institute, Neuroscience Program and Heart and	J Neurosci. 2010 Feb 3;30(5):1766-76. DOI Direct Link
The Role of Indoleamine 2,3-Dioxygenase in Retinal Pigment Epithelial Cell-mediated Immune Modulation. Purpose: To evaluate the role of indoleamine dioxygenase (IDO) in human...	5th February, 2010	Department of Ophthalmology, Dongguk University, School of Medicine,	Ocul Immunol Inflamm. 2010 Jan;18(1):24-31. DOI Direct Link
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Press Releases About Histocompatibility:
deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia	1st July, 2009	DeCODE Genetics Inc	REYKJAVIK, Iceland, July 1 /PRNewswire-FirstCall/ -- The largest study of the genetics of schizophrenia ever undertaken has revealed several new common single-letter variants in the sequence of
Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey	3rd December, 2008	Vical Incorporated	SAN DIEGO, Dec. 3 /PRNewswire-FirstCall/ -- Vical Incorporated (Nasdaq: VICL) today announced an exclusive, binding letter of intent with EIP Eczacibasi Ilac Pazarlama A.S. (EIP) for sales and
Oxford University researchers and local company work together to	1st June, 2005	Proimmune	Oxford University researchers and local company work together to accelerate HIV vaccine research Oxford, UK, 15 June 2005 …. Scientists in Oxford, developing a vaccine for HIV, hope to

BioNews Results for Histocompatibility:
Major Histocompatibility Complex Genotyping with Massively Parallel Pyrosequencing	Bionity.com:  Jan 5 2010 8:32AM Matching: histocompatibility

Histocompatibility Clinical Trials:
Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for Advanced Hematologic Malignancies

Histocompatibility Patents:
US Patent No.	Title
7638679	Tolerance and chronic hepatitis C virus
7645454	Prostate specific antigens and uses thereof
7645573	Diagnosis of sepsis or SIRS using biomarker profiles
7645613	Mass spectrometry techniques for determining the status of sepsis in an individual
7645733	Tissue protective cytokines for the treatment and prevention of sepsis and the formation of adhesions
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Companies working in the area of Histocompatibility from Bioportfolio's Biocorporate database :
Company Name
Forensic Analytical Molecular Genetics Division Comprised of leading research scientists from the field of HLA typing, Forensic Analytical's Molecular Genetics Division offers a variety of products and services that address the needs of immu... www.forensica.com/        View full profile
Altor BioScience Corporation Altor BioScience Corporation is a biopharmaceutical company developing a new class of therapeutic products for the treatment of cancer, viral infections and autoimmune diseases. Altor’s drug discovery... www.sunolmolecular.com/        View full profile

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