Histocompatibility

Histocompatibility is the property of having the same, or mostly the same, alleles of a set of genes called the major histocompatibility complex. These genes are expressed in most tissues as antigens, to which the immune system makes antibodies. The immune system at first makes antibodies to all sorts of antigens, including those it has never been exposed to, but stops making them to antigens present in the body. If the body is exposed to foreign antigens, as by getting a tissue graft, it attacks the foreign material unless it is histocompatible.A similar system exists in many plants; its purpose is not to reject grafts, but to prevent inbreeding. Pollen from a plant sharing a histocompatibility gene with the female either fails to grow or dies soon after germinating. (From the Wikpedia article Histocompatibility.)

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Recent Publications on Histocompatibility:
Trans-species polymorphism, HLA-disease associations and the evolution of the MHC. Currently, the paradigm is that major histocompatibility complex (MHC)...	13th November, 2009	University of Hull; Hull, UK.	Commun Integr Biol. 2009 Sep;2(5):408-10.
Cauterization of Central Cornea Induces Recruitment of Major Histocompatibility Complex Class II+ Langerhans Cells From Limbal Basal Epithelium. PURPOSE:: The purpose of this study was to investigate the distribution...	13th November, 2009	From the *Eye Institute, Xiamen University School of Medicine, Xiamen,	Cornea. 2009 Nov 11. DOI Direct Link
PKCtheta is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice. When used as therapy for hematopoietic malignancies, allogeneic BM...	13th November, 2009		J Clin Invest. 2009 Nov 9. pii: 39692. doi: 10.1172/JCI39692. DOI Direct Link
Acute in vivo exposure to interferon-{gamma} enables resident brain dendritic cells to become effective antigen presenting cells. Dendritic cells (DC) are the professional antigen presenting cells (APC)...	13th November, 2009	Laboratories of Neuroendocrinology and Cellular Physiology and Immunology,	Proc Natl Acad Sci U S A. 2009 Nov 11. DOI Direct Link
Immune Evasion Proteins of Murine Cytomegalovirus Preferentially Affect Cell Surface Display of Recently-Generated Peptide Presentation Complexes. For recognition of infected cells by CD8 T cells, antigenic peptides are...	13th November, 2009	Institute for Virology, University Medical Center of the Johannes	J Virol. 2009 Nov 11. DOI Direct Link
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Press Releases About Histocompatibility:
deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia	1st July, 2009	DeCODE Genetics Inc	REYKJAVIK, Iceland, July 1 /PRNewswire-FirstCall/ -- The largest study of the genetics of schizophrenia ever undertaken has revealed several new common single-letter variants in the sequence of
Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey	3rd December, 2008	Vical Incorporated	SAN DIEGO, Dec. 3 /PRNewswire-FirstCall/ -- Vical Incorporated (Nasdaq: VICL) today announced an exclusive, binding letter of intent with EIP Eczacibasi Ilac Pazarlama A.S. (EIP) for sales and
Oxford University researchers and local company work together to	1st June, 2005	Proimmune	Oxford University researchers and local company work together to accelerate HIV vaccine research Oxford, UK, 15 June 2005 …. Scientists in Oxford, developing a vaccine for HIV, hope to

BioNews Results for Histocompatibility:
American Society for Histocompatibility and Immunogenetics Hosts 2009 Annual Meeting Nov. 2-6	BioSpace:  Oct 8 2009 8:48PM Matching: histocompatibility

Histocompatibility Clinical Trials:
Minor Histocompatibility Vaccination After Allogeneic Stem Cell Transplantation for Advanced Hematologic Malignancies

Histocompatibility Patents:
US Patent No.	Title
7601887	Banana resistance genes and uses thereof
7605233	Tumour necrosis factor binding ligands
7605237	High affinity human antibodies to human IL-4 receptor
7605238	Human CTLA-4 antibodies and their uses
7608274	Therapeutic processes and useful compositions therefor
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Companies working in the area of Histocompatibility from Bioportfolio's Biocorporate database :
Company Name
Forensic Analytical Molecular Genetics Division Comprised of leading research scientists from the field of HLA typing, Forensic Analytical's Molecular Genetics Division offers a variety of products and services that address the needs of immu... www.forensica.com/        View full profile
Altor BioScience Corporation Altor BioScience Corporation is a biopharmaceutical company developing a new class of therapeutic products for the treatment of cancer, viral infections and autoimmune diseases. Altor’s drug discovery... www.sunolmolecular.com/        View full profile

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