Iduronidase

Iduronidase is an enzyme involved in the degeneration of glycosaminoglycans such as dermatan sulfate and heparan sulfate. It is found in the lysosomes of cells. (From the Wikpedia article Iduronidase.)

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Recent Publications on Iduronidase:
Structural study on mutant alpha-L-iduronidases: insight into mucopolysaccharidosis type I. To elucidate the basis of mucopolysaccharidosis type I (MPS I), we...	17th July, 2008	Department of Analytical Biochemistry, Meiji Pharmaceutical University,	J Hum Genet. 2008;53(5):467-74. Epub 2008 Mar 14. DOI Direct Link
Improved retroviral vector design results in sustained expression after adult gene therapy in mucopolysaccharidosis I mice. BACKGROUND: Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease...	10th July, 2008	Department of Internal Medicine, Washington University School of Medicine,	J Gene Med. 2008 Jul 9;. DOI Direct Link
Mucopolysaccharidoses type I and IVA: Clinical features and consanguinity in Tunisia. Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders...	1st July, 2008	Laboratory of biochemistry, Farhat-Hached Hospital, 4000 Sousse, Tunisia.	Pathol Biol (Paris). 2008 Jun 25;. DOI Direct Link
Laronidase (Aldurazyme): enzyme replacement therapy for mucopolysaccharidosis type I. BACKGROUND: Laronidase (Aldurazyme) is a recombinant formulation of...	14th June, 2008	New York University School of Medicine, 403 East 34th Street, 2nd Floor,	Expert Opin Biol Ther. 2008 Jul;8(7):1003-9. DOI Direct Link
Targeting of the CNS in MPS-IH Using a Nonviral Transferrin-alpha-L-iduronidase Fusion Gene Product. Mucopolysaccharidosis type I (Hurler syndrome) is caused by a deficiency...	5th June, 2008	[1] 1University of Minnesota Cancer Center, Minneapolis, Minnesota, USA	Mol Ther. 2008 Jun 3;. DOI Direct Link
→View more research publications.

Iduronidase Clinical Trials:
Intrathecal Enzyme Replacement for Hurler Syndrome	MPS IH (Hurler Syndrome)

Iduronidase Patents:
US Patent No.	Title
7056898	Hypersulfated disaccharides and methods of using the same for the treatment of inflammations
7129335	Methods for purifying and isolating recombinant chondroitinases
7135322	Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester .alpha.-N-acetyl glucosimanidase
7138371	Remodeling and glycoconjugation of peptides
7139666	Method for identifying or characterizing properties of polymeric units
→View more patents.

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