Iduronidase

Iduronidase is an enzyme involved in the degeneration of glycosaminoglycans such as dermatan sulfate and heparan sulfate. It is found in the lysosomes of cells. (From the Wikpedia article Iduronidase.)

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Recent Publications on Iduronidase:
Reprogramming erythroid cells for lysosomal enzyme production leads to visceral and CNS cross-correction in mice with Hurler syndrome. Restricting transgene expression to maturing erythroid cells can reduce...	12th November, 2009	Molecular and Gene Therapy Program, Division of Experimental Hematology	Proc Natl Acad Sci U S A. 2009 Nov 10. DOI Direct Link
Scheie syndrome: Enzyme replacement therapy does not prevent progression of cervical myelopathy due to spinal cord compression. Hurler-Scheie syndrome is caused by alpha-l-iduronidase deficiency. Enzyme...	7th November, 2009	Department of Paediatric Kidney, Liver and Metabolic Diseases, Hannover	J Inherit Metab Dis. 2009 Nov 4. DOI Direct Link
A Self-inactivating gamma-Retroviral Vector Reduces Manifestations of Mucopolysaccharidosis I in Mice. Mucopolysaccharidosis I (MPS I) is a lysosomal storage disease due to...	22nd October, 2009	Department of Medicine, Washington University School of Medicine, St	Mol Ther. 2009 Oct 20. DOI Direct Link
Mutational Analysis of the alpha-L-Iduronidase Gene in Three Egyptian Families: Identification of Three Novel Mutations and Five Novel Polymorphisms. Mucopolysaccharidosis type I (MPS I) is an autosomal recessive disorder...	21st October, 2009	1 Department of Medical Molecular Genetics, National Research Centre ,	Genet Test Mol Biomarkers. 2009 Oct 19. DOI Direct Link
Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. The Sleeping Beauty (SB) transposon system is a nonviral vector that...	14th October, 2009	Department of Genetics, Cell Biology and Development, Center for Genome	Mol Ther. 2009 Jul;17(7):1136-44. Epub 2009 Apr 21. DOI Direct Link
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Iduronidase Patents:
US Patent No.	Title
7341720	Targeting of glycoprotein therapeutics
7439043	Galactosyl nucleotide sugars
7442372	Delivery of therapeutic compounds to the brain and other tissues
7445930	Method for the production and purification of adenoviral vectors
7446098	Combination therapy for treating protein deficiencies
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