Immunoglobulin Switch Region

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Recent Publications on Immunoglobulin Switch Region:
Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. We report a remarkable association of recurrent (stereotyped) cytogenetic...	4th July, 2008		Haematologica. 2008 Mar;93(3):473-4. DOI Direct Link
ICOS-Dependent and -independent functions of memory CD4 T cells in allograft rejection. Donor-reactive memory T cells undermine the survival of transplanted...	19th April, 2008	Department of Immunology, the Cleveland Clinic Foundation, Cleveland, OH,	Am J Transplant. 2008 Mar;8(3):497-506. DOI Direct Link
Activation-induced cytidine deaminase induces DNA break repair events more frequently in the Ig switch region than other sites in the mammalian genome. Activation-induced cytidine deaminase (AID) produces DNA breaks in...	29th February, 2008	Department of Molecular and Cellular Biology, College of Biological	Eur J Immunol. 2007 Dec;37(12):3529-39. DOI Direct Link
S-S synapsis during class switch recombination is promoted by distantly located transcriptional elements and activation-induced deaminase. Molecular mechanisms underlying synapsis of activation-induced deaminase...	17th January, 2008	Department of Microbiology and Immunology, University of Illinois College	Immunity. 2007 Nov;27(5):711-22. Epub 2007 Nov 1. DOI Direct Link
Mechanism of R-loop formation at immunoglobulin class switch sequences. R-loops have been described in vivo at the immunoglobulin class switch...	12th January, 2008	USC Norris Comprehensive Cancer Ctr., Rm. 5428, 1441 Eastlake Ave.,	Mol Cell Biol. 2008 Jan;28(1):50-60. Epub 2007 Oct 22. DOI Direct Link
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Immunoglobulin Switch Region Patents:
US Patent No.	Title
5545806	Ransgenic non-human animals for producing heterologous antibodies
6312694	Cancer treatment methods using therapeutic conjugates that bind to aminophospholipids
6323185	Anti-viral guanosine-rich oligonucleotides and method of treating HIV
6342219	Antibody compositions for selectively inhibiting VEGF
6342221	Antibody conjugate compositions for selectively inhibiting VEGF
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