Immunohistochemistry

Immunohistochemistry or IHC refers to the process of localizing proteins in cells of a tissue section exploiting the principle of antibodies binding specifically to antigens in biological tissues. It takes its name from the roots "immuno," in reference to antibodies used in the procedure, and "histo," meaning tissue. Immunohistochemical staining is widely used in the diagnosis and treatment of cancer. Specific molecular markers are characteristic of particular cancer types. IHC is also widely used in basic research to understand the distribution and localization of biomarkers in different parts of a tissue.Visualising an antibody-antigen interaction can be accomplished in a number of ways. In the most common instance, an antibody is conjugated to an enzyme, such as peroxidase, that can catalyse a colour-producing reaction . Alternatively, the antibody can also be tagged to a fluorophore, such as FITC, rhodamine, Texas Red, Alexa Fluor, or DyLight Fluor. The latter method is of great use in confocal laser scanning microscopy, which is highly sensitive and can also be used to visualise interactions between multiple proteins. (From the Wikpedia article Immunohistochemistry.)

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Recent Publications on Immunohistochemistry:
Brain derived neurotrophic factor (BDNF) contributes to the pain hypersensitivity following surgical incision in the rats. ABSTRACT: BACKGROUND: The pathogenic role of brain derived neurotrophic...	19th July, 2008		Mol Pain. 2008 Jul 17;4(1):27. DOI Direct Link
Implications of tyrosine phosphoproteomics in cervical carcinogenesis. ABSTRACT: BACKGROUND: Worldwide cervical cancer remains a leading cause of...	19th July, 2008		J Carcinog. 2008 Jul 17;7(1):2. DOI Direct Link
Recent developments in vulvovaginal pathology. This review discusses recent developments in vulvovaginal pathology. A...	19th July, 2008	Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK.	Histopathology. 2008 Jul 11;. DOI Direct Link
MUC16 expression during embryogenesis, in adult tissues, and ovarian cancer in the mouse. Cancer antigen 125 (CA125) is an antigen that is elevated in the serum of...	19th July, 2008	Department of Molecular Genetics M. D. Anderson Cancer Center University	Differentiation. 2008 Jul 2;. DOI Direct Link
Monocyte Chemoattractant Protein-1 Plays a Dominant Role in the Chronic Inflammation Observed in Alzheimer's Disease. Chronic neuroinflammation correlates with cognitive decline and brain...	19th July, 2008	Prince of Wales Medical Research Institute, Barker Street, Randwick,	Brain Pathol. 2008 Jul 10;. DOI Direct Link
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BioNews Results for Immunohistochemistry:
Multiple Cellular Mechanisms Related to Cyclin A1 in Prostate Cancer Invasion and Metastasis	Journal of the National Cancer Institute:  Jul 15 2008 10:21PM Matching: immunohistochemistry
N-cadherin serves as diagnostic biomarker in intrahepatic and perihilar cholangiocarcinomas	Nature:  Jul 11 2008 2:57PM Matching: immunohistochemistry
Key Challenges and Issues facing the World Immunoassay Instruments Market	Macro World Investor:  Jul 2 2008 5:50PM Matching: immunohistochemistry
Platelet-derived Growth Factor Expression and Function in Idiopathic Pulmonary Arterial Hypertension	Therapeutics Daily:  Jul 1 2008 1:05PM Matching: immunohistochemistry
NextGen Sciences and Expression Pathology to provide protein biomarker discovery and measurement in tissue	BioPortfolio:  Jul 1 2008 10:49AM Matching: immunohistochemistry
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Immunohistochemistry Clinical Trials:
Diagnostic Study of Patients With Stage I Testicular Cancer	Testicular Germ Cell Tumor

Immunohistochemistry Patents:
US Patent No.	Title
7390878	PRO6090 polypeptides
7393684	Immunoconjugates of anti-IL-20 antibodies and hybridoma cell lines expressing anti-IL-20 antibodies
7393823	HER-2 binding antagonists
7393917	PRO1482 polypeptides
7393931	Secreted and transmembrane polypeptides and nucleic acids encoding the same
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Companies working in the area of Immunohistochemistry from Bioportfolio's Biocorporate database :
Company Name
DAKO A Danish company with over 1,000 products related to antibodies and antibody technology, including clinical immunohistochemistry, flow cytometry, immunocytochemistry, hybridization, microbiology,... www.dako.com/        View full profile
Dako Incorporated Identification of the origins of tumors and other diseases in body tissues has made great strides over the past two decades. As researchers expand their knowledge of cellular antigens and how these... www.dako.com/        View full profile
CytoLogix CytoLogix Corporation develops and commercializes systems for the automation of slide-based cellular diagnostics. The company's lead product, the Artisan™ Staining System, is used in Histology and... www.cytologix.com/        View full profile
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