Immunophilins

In molecular biology, immunophilins are peptidyl-prolyl isomerases that intraconvert between the cis and trans positions. Immunophilins are targeted by immunosuppressive drugs such as rapamycin, cyclosporin, and FK-506. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. However, this isomerase activity appears to be unrelated to their ability to bind these drugs. (From the Wikpedia article Immunophilins.)

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Recent Publications on Immunophilins:
FKBP Family Proteins: Immunophilins with Versatile Biological Functions. Immunophilins consist of a family of highly conserved proteins binding...	19th July, 2008	School of Biological Science, Nanyang Technological University, Singapore,	Neurosignals. 2008 Jul 18;16(4):318-325. DOI Direct Link
Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: Heat shock protein 70 levels are modulated in microglial cells. Functional loss after spinal cord injuries is originated by primary and...	26th June, 2008	Group of Neuroplasticity and Regeneration, Institute of Neurosciences and	Neuroscience. 2008 Jun 5;. DOI Direct Link
Pharmacodynamic monitoring of calcineurin phosphatase activity in transplant patients treated with calcineurin inhibitors. Calcineurin inhibitors, tacrolimus and cyclosporine, have been widely used...	25th June, 2008	Department of Clinical Pharmacy and Education, Graduate School of	Drug Metab Pharmacokinet. 2008;23(3):150-7.
Spliceosomal immunophilins. The spliceosome is a dynamic, macromolecular complex, which removes...	12th June, 2008	Florida International University, Department of Biological Sciences,	FEBS Lett. 2008 Jul 9;582(16):2345-51. Epub 2008 Jun 9. DOI Direct Link
Computational Anti-AIDS Drug Design Based on the Analysis of the Specific Interactions Between Immunophilins and the HIV-1 gp120 V3 Loop. Application to the FK506-Binding Protein. The object of the study was to model the structural complex of the...	7th June, 2008	Institute of Bioorganic Chemistry, National Academy of Sciences of	J Biomol Struct Dyn. 2008 Aug;26(1):49-56.
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Immunophilins Clinical Trials:
Effects of Ligands on Human Hair Follicles Grafted Onto SCID Mice	Alopecia Intervention: Drug: FK506, GP11046, GP11511

Immunophilins Patents:
US Patent No.	Title
7195760	Anti-pro363 antibodies
7244423	Methods for therapy of neurodegenerative disease of the brain
7244575	Soluble complex comprising a retroviral surface glycoprotein
7247650	Macrolides and methods for producing same
7253169	Aza compounds, pharmaceutical compositions and methods of use
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