Immunophilins

In molecular biology, immunophilins are peptidyl-prolyl isomerases that intraconvert between the cis and trans positions. Immunophilins are targeted by immunosuppressive drugs such as rapamycin, cyclosporin, and FK-506. For these drugs in particular, known immunophilins such as cyclophilin catalyze the cis-trans isomerization of peptide bonds, particularly X-Pro peptide bonds. However, this isomerase activity appears to be unrelated to their ability to bind these drugs. (From the Wikpedia article Immunophilins.)

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Recent Publications on Immunophilins:
Myocardial release of FKBP12 and increased production of FKBP12.6 in ischemia and reperfusion experimental models. BACKGROUND: Coronary artery occlusion and reperfusion may trigger...	3rd November, 2009	Department of Cardiology, Sahlgrenska University Hospital, Gothenburg,	Biochem Biophys Res Commun. 2009 Oct 28. DOI Direct Link
Diabetic neuropathy: therapies on the horizon. OBJECTIVES: This is a review of emerging interventions from the recent...	23rd October, 2009	Department of Pharmacology, Hamdard University, Hamdard Nagar, New Delhi	J Pharm Pharmacol. 2009 Sep;61(9):1137-45. DOI Direct Link
Treatment of focal segmental glomerulosclerosis with immunophilin modulation: when did we stop thinking about pathogenesis? Nephrotic focal segmental glomerulosclerosis (FSGS) represents a difficult...	23rd October, 2009	Department of Nephrology, University Paris-Descartes, Hopital Georges	Kidney Int. 2009 Sep;76(5):487-91. Epub 2009 Jun 3. DOI Direct Link
Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder. Mood disorders associated with dysfunction of the...	21st October, 2009	Department of Psychiatry, University of California at San Diego, La Jolla,	Brain Res. 2009 Aug 25;1286:1-12. Epub 2009 Jun 21. DOI Direct Link
Individualizing Calcineurin Inhibitor Therapy in Renal Transplantation - Current Limitations and Perspectives. Patient variability in clinical response to the calcineurin inhibitors...	20th October, 2009	Leiden University Medical Center, Department of Clinical Pharmacy and	Curr Pharm Des. 2009 Oct 15.
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Immunophilins Patents:
US Patent No.	Title
7378105	Drug delivery systems, kits, and methods for administering zotarolimus and paclitaxel to blood vessel lumens
7445904	Cysteine string protein and its role in neurodegenerative diseases
7455853	Medical devices containing rapamycin analogs
7456315	Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
7465718	Ansamycins having improved pharmacological and biological properties
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