Insulinoma

An insulinoma is a tumour of the pancreas derived from the beta cells which while retaining the ability to synthesize and secrete insulin is autonomous of the normal feedback mechanisms. Patients present with symptomatic hypoglycemia which is ameliorated by feeding. The diagnosis of an insulinoma is usually made biochemically with low blood sugar, elevated insulin, pro-insulin and C-peptide levels and confirmed by medical imaging or angiography. The definitive treatment is surgery. (From the Wikpedia article Insulinoma.)

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Recent Publications on Insulinoma:
Cervical metastases of glucagonoma in a patient with multiple endocrine neoplasia type 1: Report of a case. Multiple endocrine neoplasia type 1 (MEN 1) is a syndrome characterized by...	29th November, 2008	Department of Digestive Surgery, Pontificia Universidad Catolica de Chile,	Surg Today. 2008;38(12):1137-43. Epub 2008 Nov 28. DOI Direct Link
Spleen-preserving distal pancreatectomy. Introduction: Splenectomy is routinely performed in conventional distal...	28th November, 2008	Department of General Surgery, Singapore General Hospital, Outram Road,	Singapore Med J. 2008 Nov;49(11):883-5.
Expression and function of alphabeta1 integrins in pancretic beta (INS-1) cells. Integrin-extracellular matrix interactions are important determinants of...	22nd November, 2008	Children's Health Research Institute, University of Western Ontario,	J Cell Commun Signal. 2008 Nov 21. DOI Direct Link
CXCL12/SDF-1 over-expression in human insulinomas and its biological relevance. This study was performed on the basis of previously obtained investigative...	18th November, 2008	Department of Internal Medicine III, Medical University of Vienna,	Mol Cell Endocrinol. 2008 Oct 22. DOI Direct Link
Insulinomatosis: A Multicentric Insulinoma Disease that Frequently Causes Early Recurrent Hyperinsulinemic Hypoglycemia. BACKGROUND: Multicentric insulinoma disease was characterized with regard...	18th November, 2008	Departments of *Pathology parallelGeneral and Visceral Surgery musical	Am J Surg Pathol. 2008 Nov 13. DOI Direct Link
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BioNews Results for Insulinoma:
Study results from A. Bgu-Le Corroller et al provide new insights into insulinoma therapy	Calibre Macro World:  Oct 24 2008 1:55AM Matching: insulinoma

Insulinoma Clinical Trials:
Laparoscopy to Remove Pancreatic Tumors (Insulinomas)	Insulinoma Intervention: Procedure: Intraoperative ultrasound

Insulinoma Patents:
US Patent No.	Title
7368527	HADDE71 polypeptides
7393667	Stereoselective reduction process for the preparation of pyrrolotriazine compounds
7393861	Derivatives of 4-aminopiperidine and their use as a medicament
7396659	Inhibitors of nitric oxide synthase to treat type 1 diabetes
7396663	Isolated polynucleotide encoding a G-protein coupled receptor
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