Insulinoma

An insulinoma is a tumour of the pancreas derived from the beta cells which while retaining the ability to synthesize and secrete insulin is autonomous of the normal feedback mechanisms. Patients present with symptomatic hypoglycemia which is ameliorated by feeding. The diagnosis of an insulinoma is usually made biochemically with low blood sugar, elevated insulin, pro-insulin and C-peptide levels and confirmed by medical imaging or angiography. The definitive treatment is surgery. (From the Wikpedia article Insulinoma.)

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Recent Publications on Insulinoma:
Biological activity of EXf, a peptide analogue of exendin-4. Exendin-4 is an incretin mimetic that has been developed for the treatment...	19th November, 2009	Department of Pharmacology, Institute of Materia Medica, Chinese Academy	Eur J Pharmacol. 2009 Nov 14. DOI Direct Link
[Case of incidental pancreatic tumor] BACKGROUND: Organic hyperinsulinism causes hypoglycaemia manifesting...	18th November, 2009		Nippon Naika Gakkai Zasshi. 2009 Aug 10;98(8):2031-2, 2054-5.
ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells. Pancreatic beta-cell loss represents a key factor in the pathogenesis of...	17th November, 2009	Department of Cardiology, Lund University, 22185, Lund, Sweden.	Cell Mol Life Sci. 2009 Nov 14. DOI Direct Link
Limited Value of 18F-F-DOPA PET to Localize Pancreatic Insulin-Secreting Tumors in Adults with Hyperinsulinemic Hypoglycemia. Context: Fluorine-18-L-dihydroxyphenylalanine positron emission tomography...	17th November, 2009	Service Central de Biophysique et de Medecine Nucleaire (L.T., D.T.,	J Clin Endocrinol Metab. 2009 Nov 13. DOI Direct Link
A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas-kidney transplantation from cardiac death donor. AIMS/HYPOTHESIS: A 41-year-old woman undergoing simultaneous...	17th November, 2009	Department of Medicine and Clinical Science, Graduate School of Medical	Diabetologia. 2009 Nov 13. DOI Direct Link
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BioNews Results for Insulinoma:
Pancreatic Endocrine Tumors: Expression Profiling Evidences a Role for AKT-mTOR Pathway [Gastrointestinal Canc	Journal of Clinical Oncology:  Nov 19 2009 6:30AM Matching: insulinoma
Health Matters : Insulinoma ?	PR inside:  Nov 8 2009 2:53AM Matching: insulinoma
Spermidine regulates insulin synthesis and cytoplasmic Ca(2+) in mouse beta-TC6 insulinoma cells	Bioscience Technology Online:  Nov 7 2009 3:46AM Matching: insulinoma
Diagnosis of insulinoma in a patient with hypoglycemia without obvious hyperinsulinemia - this content is FREE	Nature:  Nov 2 2009 10:34AM Matching: insulinoma
Diagnosis of insulinoma in a patient with hypoglycemia without obvious hyperinsulinemia	Nature Reviews Endocrinology:  Oct 21 2009 10:31AM Matching: insulinoma
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Insulinoma Patents:
US Patent No.	Title
7572442	Selected antibody compositions for binding to aminophospholipids
7582608	Selective VPAC2 receptor peptide agonists
7582668	Imidazoyl-benzamide anti-cancer agents
7585499	Method for encapsulation of cellular material using a charged initiator polymer
7585509	Erb-2 receptor targeting peptide
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