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KeratoacanthomaKeratoacanthoma is a relatively common, benign, epithelial tumor that was previously considered to be a variant of squamous cell carcinoma . The etiology is unknown. No human papillomavirus-DNA sequences were detected in lesions by polymerase chain reaction. It is a disease of the elderly with an annual incidence rate of 104 per 100,000. It is not associated with internal malignancy. There may be a seasonal presentation of keratoacanthoma that suggests that ultraviolet radiation has an acute effect on the development of KA. KAs may develop in sites of previous trauma. Most cases are the “crateriform†type, which grow rapidly then undergo spontaneous regression. Less than 2% belong to the rare destructive variants with no regression and persistent invasive growth. These are referred to as keratoacanthoma marginatum centrifugum and mutilating keratoacanthomas and can lead to severe defects. KA begins as a smooth, dome-shaped, red papule that resembles molluscum contagiosum. In a few weeks the tumor may rapidly expand to 1 or 2cm and develop a central keratin-filled crater that is frequently filled with crust. The growth retains its smooth surface, unlike a squamous cell carcinoma. Untreated, growth stops in approximately 6 weeks, and the tumor remains unchanged for an indefinite period. In the majority of cases it then regresses slowly over 2 to 12 months and frequently heals with scarring. The limbs, particularly the sun-exposed hands and arms, are the most common site; the trunk is the second most common site, but KA may occur on any skin surface, including the anal area. On occasion, multiple KAs appear, or a single lesion extends over several centimeters. These variants resist treatment and are unlikely to undergo spontaneous emission.According to a review of literature by Robert A. Schwartz, KA was once considered a benign neoplasm that resembled a highly malignant one , but it is now viewed in an opposite light as a cancer that resembles a benign neoplasm . KA is an abortive malignancy that rarely progresses into an invasive SCC. The KA may serve as a marker for the important autosomal dominant familial cancer syndrome, the Muir-Torre syndrome, as a result of a defective DNA mismatch repair gene.[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=14871228&query_hl=2&itool=pubmed_docsum] (From the Wikpedia article Keratoacanthoma.) Download PDF Image ResultsLoading...
BioPortfolio Ltd. offers e-mail and postal lists for Keratoacanthoma scientists - we have details of around 155 individuals working on Keratoacanthoma . This page has been viewed 131 times Recent Search Terms used to find this page: keratoacanthoma | keratoacanthoma | keratoacanthoma | keratoacanthoma | keratoacanthoma | keratoacanthoma | keratoacanthoma | keratoacanthoma and the incidence of scc | keratoacanthoma | . Browse BioPortfolio's InDepth service - alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z or by Most Publications, recently searched for, or most viewed. Search for Keratoacanthoma across BioPortfolio, or bestselling Keratoacanthoma books or recently published Keratoacanthoma books . Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. | |||||||||||||||||||||||||||||||||||||||||||||||
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