Ketoglutarate Dehydrogenase Complex

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Recent Publications on Ketoglutarate Dehydrogenase Complex:
Impact of short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs onmitochondrial energy metabolism. Accumulation of organic acids as well as their CoA and carnitine esters in...	28th June, 2008	Department of General Pediatrics, Division of Inborn Metabolic Diseases,	Biochim Biophys Acta. 2008 Jun 3;. DOI Direct Link
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Tumor cells extensively utilize the pentose phosphate pathway for the...	10th June, 2008	Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, USA.	Bioorg Med Chem Lett. 2008 Mar 15;18(6):2206-10. Epub 2007 Dec 3. DOI Direct Link
Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease. Measures in autopsied brains from Alzheimer's Disease (AD) patients reveal...	15th May, 2008	Department of Neurology and Neuroscience, Weill Medical College of Cornell	Biochim Biophys Acta. 2008 Apr;1782(4):229-38. Epub 2007 Dec 31. DOI Direct Link
Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins. Structural relationship within the family of the thiamine...	3rd May, 2008	School of Bioinformatics and Bioengineering, Lomonosov Moscow State	Proteins. 2008 May 1;71(2):874-90. DOI Direct Link
Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases. Mitochondrial defects including reduction of a key mitochondrial...	22nd April, 2008	Department of Neurology and Neuroscience, Weill Medical College of Cornell	Neuroscience. 2008 Jun 2;153(4):986-96. Epub 2008 Mar 18. DOI Direct Link
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Ketoglutarate Dehydrogenase Complex Clinical Trials:
Brain Energy Metabolism in Patients With Chronic Liver Disease and Impaired Central Nervous System	Cirrhosis;   Hepatic Encephalopathy

Ketoglutarate Dehydrogenase Complex Patents:
US Patent No.	Title
5393671	Mutant Escherichia coli capable of enhanced L-glutamic acid production
6387945	Lipoic acid analogs
6500571	Enzymatic fuel cell
6500670	Plant pyruvate dehydrogenase kinase gene
6596701	S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
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