Recent Publications on Ketoglutarate Dehydrogenase Complex: |  |
All-atom replica exchange molecular simulation of protein BBL.
Downhill folding is one of the most important predictions of energy...
Direct Link | 30th August, 2008
| Department of Physics, National Laboratory of Solid State Microstructure,
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High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.
Nicotinamide, the principal form of niacin (vitamin B3), has been proposed...
Direct Link | 21st August, 2008
| Institute for Nutritional Science, Shanghai Institutes of Biological
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Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes.
Dimethyl amiloride (DMA) enhances insulin secretion in the pancreatic...
Direct Link | 23rd July, 2008
| Department of Molecular Physiology and Biophysics, Vanderbilt University
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Impact of short- and medium-chain organic acids, acylcarnitines, and acyl-CoAs onmitochondrial energy metabolism.
Accumulation of organic acids as well as their CoA and carnitine esters in...
Direct Link | 28th June, 2008
| Department of General Pediatrics, Division of Inborn Metabolic Diseases,
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Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.
Tumor cells extensively utilize the pentose phosphate pathway for the...
Direct Link | 10th June, 2008
| Array BioPharma Inc., 3200 Walnut Street, Boulder, CO 80301, USA.
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Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.
Measures in autopsied brains from Alzheimer's Disease (AD) patients reveal...
Direct Link | 15th May, 2008
| Department of Neurology and Neuroscience, Weill Medical College of Cornell
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Structure-function relationships in the 2-oxo acid dehydrogenase family: substrate-specific signatures and functional predictions for the 2-oxoglutarate dehydrogenase-like proteins.
Structural relationship within the family of the thiamine...
Direct Link | 3rd May, 2008
| School of Bioinformatics and Bioengineering, Lomonosov Moscow State
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Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases.
Mitochondrial defects including reduction of a key mitochondrial...
Direct Link | 22nd April, 2008
| Department of Neurology and Neuroscience, Weill Medical College of Cornell
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Dual role for a bacteriophytochrome in the bioenergetic control of Rhodopseudomonas palustris: enhancement of photosystem synthesis and limitation of respiration.
In the purple photosynthetic bacterium Rhodopseudomonas palustris, far-red...
Direct Link | 9th April, 2008
| CEA Cadarache, DSV/IBEB/SBVME/LBC, UMR 6191 CNRS/CEA/Univ Aix-Marseille,
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Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.
We have previously demonstrated that when cardiac mitochondria were...
Direct Link | 1st March, 2008
| Free Radical Biology and Aging Research Program, Oklahoma Medical Research
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The role of loop and beta-turn residues as structural and functional determinants for the lipoyl domain from the Escherichia coli 2-oxoglutarate dehydrogenase complex.
The lipoyl domain of the dihydrolipoyl succinyltransferase (E2o) component...
Direct Link | 13th February, 2008
| Department of Biochemistry, University of Cambridge, 80 Tennis Court Road,
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Endotoxin challenge reduces aconitase activity in myocardial tissue.
Sepsis impairs mitochondrial respiration but the mechanisms responsible...
Direct Link | 9th January, 2008
| Division of Pediatric Critical Care, Department of Pediatrics, Case
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| [Characteristic metabolic disturbances in the rat tissues caused by long-term use of alcohol]
| 27th December, 2007
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The differential effects of superoxide anion, hydrogen peroxide and hydroxyl radical on cardiac mitochondrial oxidative phosphorylation.
The involvement of reactive oxygen species (ROS) in cardiac...
Direct Link | 21st December, 2007
| INSERM, U841, Creteil, F-94010, France.
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| Long-term abnormalities in brain glucose/energy metabolism after inhibition of the neuronal insulin receptor: implication of tau-protein.
| 11th December, 2007
| Institute of Pathology, University of Heidelberg, Heidelberg, Germany.
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