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Lactase

Lactase , a member of the β-galactosidase family of enzymes, is a glycoside hydrolase involved in the hydrolysis of the disaccharide lactose into constituent galactose and glucose monomers. In humans, lactase is present predominantly along the brush border membrane of the differentiated enterocytes lining the villi of the small intestine.Lactase is essential for digestive hydrolysis of lactose in milk. Deficiency of the enzyme causes lactose intolerance.The optimum temperature for lactase is about 48 °C for its activity and has an optimum pH of 6.5. (From the Wikpedia article Lactase.)

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Recent Publications on Lactase:

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SODIUM TUNGSTATE DECREASES SUCRASE AND Na+/D-GLUCOSE COTRANSPORTER IN THE JEJUNUM OF DIABETIC RATS.
Sodium tungstate reduces glycemia and reverts the diabetic phenotype in...
12th July, 2008
Departament de Fisiologia (Farmacia& Institut de Recerca de la Nutricio i Am J Physiol Gastrointest Liver Physiol. 2008 Jul 10;.
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Can primary hypolactasia manifest itself after the age of 20 years? A two-decade follow-up study.
Objective. The age at manifestation of primary hypolactasia varies between...
9th July, 2008
Valio Ltd., Helsinki, Finland. Scand J Gastroenterol. 2008 Apr 30;:1-6.
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Genetic testing for adult-type hypolactasia in Italian families.
Abstract Background: Adult-type hypolactasia is characterized by the...
9th July, 2008
1Department of Mother and Child, Biology and Genetics, University of Clin Chem Lab Med. 2008 May 21;.
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Lactase Production by Solid-state Cultivation of Kluyveromyces marxianus CDBBL 278 on an Inert Support: Effect of Inoculum, Buffer, and Nitrogen Source.
A study was carried out to select the conditions for cultivation of...
2nd July, 2008
Departamento de Biotecnologia, Universidad Autonoma Metropolitana Appl Biochem Biotechnol. 2008 Jul 1;.
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Production, purification, and characterization of a potential thermostable galactosidase for milk lactose hydrolysis from Bacillus stearothermophilus.
Beta-galactosidase, commonly named lactase, is one of the most important...
1st July, 2008
State Key Laboratory of Food Science and Technology, School of Food J Dairy Sci. 2008 May;91(5):1751-8.
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Lactase Clinical Trials:

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Effects of Lactose on Fecal Microflora
Effect of Lactose-Lactase Interaction on Microflora Interventions: Dietary Supplement: lactose;   Dietary Supplement: lactose
Diagnostic Strategies in Patients Suspected of Irritable Bowel Syndrome
Irritable Bowel Syndrome

Lactase Patents:

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US Patent No.Title
7303871 Enzyme treatment of foodstuffs for Celiac Sprue
7320876 Phytase-containing animal food and method
7320998 Carbohydrate analog inhibitors of alpha-amylase
7329424 Process for manufacturing cheeses and other dairy products and products thereof
7329529 Ubiqutin proteases

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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