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Lactase

Lactase , a member of the β-galactosidase family of enzymes, is a glycoside hydrolase involved in the hydrolysis of the disaccharide lactose into constituent galactose and glucose monomers. In humans, lactase is present predominantly along the brush border membrane of the differentiated enterocytes lining the villi of the small intestine.Lactase is essential for digestive hydrolysis of lactose in milk. Deficiency of the enzyme causes lactose intolerance.The optimum temperature for lactase is about 48 °C for its activity and has an optimum pH of 6.5. (From the Wikpedia article Lactase.)

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Recent Publications on Lactase:

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Flame synthesis and in vitro biocompatibility assessment of superparamagnetic iron oxide nanoparticles: cellular uptake, toxicity and proliferation studies.
Superparamagnetic iron oxide nanoparticles are used in diverse...
17th November, 2009
Mechanical Engineering and Mechanics Department, Drexel University, J Nanosci Nanotechnol. 2009 Dec;9(12):6834-43.
The origins of lactase persistence in Europe.
Lactase persistence (LP) is common among people of European ancestry, but...
17th November, 2009
Research Department of Genetics, Evolution and Environment, University PLoS Comput Biol. 2009 Aug;5(8):e1000491. Epub 2009 Aug 28.
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Lactose intolerance and African Americans: implications for the consumption of appropriate intake levels of key nutrients.
Lactose intolerance is a complex condition that is complicated by cultural...
11th November, 2009
J Natl Med Assoc. 2009 Oct;101(10 Suppl):5S-23S.
Lack of effect of lactose digestion status on baseline fecal micoflora.
BACKGROUND: The genetics of intestinal lactase divide the world's...
7th November, 2009
Sir Mortimer B Davis Jewish General Hospital, McGill University School of Can J Gastroenterol. 2009 Nov;23(11):753-9.
Frequency of lactose malabsorption among healthy southern and northern Indian populations by genetic analysis and lactose hydrogen breath and tolerance tests.
BACKGROUND: Lactose malabsorption (LM), the inability to break down...
6th November, 2009
Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Am J Clin Nutr. 2009 Nov 4.
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Lactase Patents:

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US Patent No.Title
7530804 System and process for providing at least one opening in dosage forms
7544477 Circularly permutated, interaction-activated proteins
7544795 Recombinant hexose oxidase, a method of producing same and use of such enzyme
7547534 Methods for making a composition to treat a wood, a pulp or a paper
7550279 Amylose and amylopectin derivatives

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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