Macroglossia

Macroglossia is the medical term for unusual enlargement of the tongue. Severe enlargement of the tongue can cause cosmetic and functional difficulties including in speaking, eating, swallowing and sleeping. Macroglossia is common in primary and myeloma-related amyloidosis. Amyloidosis is an accumulation of insoluble proteins in tissues that impedes normal function. Macroglossia is also a clinical feature in congenital hypothyroidism, rare genetic syndromes such as Beckwith-Wiedemann syndrome and immunodeficiency, centromere instability and facial anomalies syndrome, acromegaly and Hurler syndrome. (From the Wikpedia article Macroglossia.)

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Recent Publications on Macroglossia:
[Shoulder pad and macroglossia: two signs of amyloidosis.] The nuclear presence of the expanded disease proteins is of critical...	6th November, 2009	Servicio de Medicina Interna. Hospital Da Barbanza. Oleiros-Ribeira. La	Rev Clin Esp. 2009 Nov;209(10):521-2.
Tongue reduction in Beckwith-Wiedemann syndrome with CO(2) laser. Beckwith-Wiedemann syndrome is a congenital syndrome with some anomaly in...	3rd November, 2009	Department of Otorhinolaryngology, Istanbul University, Cerrahpa-a Medical	J Craniofac Surg. 2009 Jul;20(4):1202-3. DOI Direct Link
Obstructive sleep apnea in a patient with the Melkersson-Rosenthal syndrome. INTRODUCTION: Melkersson-Rosenthal syndrome (MRS) is a rare disorder of...	29th October, 2009	University of Giessen Lung Center, Giessen, Germany.	Sleep Breath. 2009 Oct 28. DOI Direct Link
Mandibular prognathism caused by acromegaly - a surgical orthodontic case. A 22-year-old man presented for orthodontic surgery because of mandibular...	23rd October, 2009	Department of Cranio-Maxillo-Facial Surgery, University of Regensburg,	Head Face Med. 2009 Aug 6;5:16. DOI Direct Link
A case of Beckwith-Wiedemann syndrome caused by a cryptic 11p15 deletion encompassing the centromeric imprinted domain of the BWS locus. Beckwith-Wiedemann syndrome is a clinically variable and genetically...	22nd October, 2009	1 Istituto di Genetica Medica, Universita Cattolica Sacro Cuore,	J Med Genet. 2009 Oct 20. DOI Direct Link
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BioNews Results for Macroglossia:
Does Sleep Apnea Underlie Your Patients Refractory Hypertension?	Consultant Live:  Nov 4 2009 10:27PM Matching: macroglossia

Macroglossia Patents:
US Patent No.	Title
7598269	Methods and compositions for treating amyloid-related diseases
6875434	Methods of treatment of Alzheimer's disease
6727242	Pharmacological treatment for sleep apnea
6693077	Keratinocyte growth factor-2
6555564	Neuropharmacological treatments of sleep-related breathing disorders
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BioPortfolio Ltd. offers e-mail and postal lists for Macroglossia scientists - we have details of around 86 individuals working on Macroglossia .