Macronucleus

A macronucleus is the larger type of nucleus in ciliates. Macronuclei are polyploid and undergo direct division without mitosis. It controls the non-reproductive cell functions such as metabolism. During conjugation, the macronucleus disingtegrates, and a new macronucleus is formed by karyogamy of the micronuclei. The macronucleus contains hundreds of chromosomes, each present in ~50 copies. The macronucleus lacks a mechanism to precisely partition this complex genome equally during nuclear division; thus how the cell manages to maintain a balanced genome after generations of divisions is a mystery.Protozoan nucleus: the larger of two nuclei in most ciliate protozoans, involved in nonreproductive functions such as feeding and metabolismCategory:Organelles Macrophages (From the Wikpedia article Macronucleus.)

Download PDF

Recent Publications on Macronucleus:
Nuclear localization of eukaryotic class II release factor (eRF3): implication for the multifunction of eRF3 in ciliates Euplotes cell. Class II polypeptide release factor (eRF3), a ribosome and eRF1-dependent...	28th June, 2008	Institute of Biotechnology, Key Laboratory of Chemical Biology and	Cell Biol Int. 2008 Mar;32(3):353-7. Epub 2008 Jan 9. DOI Direct Link
Developmentally programmed DNA splicing in Paramecium reveals short-distance crosstalk between DNA cleavage sites. Somatic genome assembly in the ciliate Paramecium involves the precise...	25th June, 2008	Ecole Normale Superieure, Laboratoire de Genetique Moleculaire, 75005	Nucleic Acids Res. 2008 Jun;36(10):3244-51. Epub 2008 Apr 17. DOI Direct Link
Chromatin extrusion in resting encystment of Colpoda cucullus: a possible involvement of apoptosis-like nuclear death. The extrusion of macronuclear chromatin is a remarkable characteristic...	13th June, 2008	Institute of Biological Science, Faculty of Science, Kochi University,	Cell Biol Int. 2008 Jan;32(1):31-8. Epub 2007 Sep 4. DOI Direct Link
The pathway to detangle a scrambled gene. BACKGROUND: Programmed DNA elimination and reorganization frequently occur...	5th June, 2008	Institute of Cell Biology, University Witten/Herdecke, Witten, Germany.	PLoS ONE. 2008 Jun 4;3(6):e2330. DOI Direct Link
[Histone-antihistone interactions in the Escherichia coli-Tetrahymena pyriformis association] Using the Escherichia coli-Tetrahymena pyriformis system, we revealed the...	5th June, 2008		Mikrobiologiia. 2008 Mar-Apr;77(2):219-25.
→View more research publications.

Macronucleus Patents:
US Patent No.	Title
6943279	Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use
7057020	Isolated RuvB polypeptides
7060480	MRE11 orthologue and uses thereof
7070929	Genetic markers for improved disease resistance in animals (BPI)
7081518	Anti-mesothelin antibodies having high binding affinity
→View more patents.

BioPortfolio Ltd. offers e-mail and postal lists for Macronucleus scientists - we have details of around 60 individuals working on Macronucleus .

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.  See User Agreement

Send comments and feedback to:
Peter Barfoot Managing Director, BioPortfolio Ltd.
UK Tel: (+44) 1300 321501
USA Voicemail and Fax: (+1) 415 680 2472

All rights reserved. All other trademarks recognized.

BioPortfolio Limited is registered in England & Wales at Wessex Barn, Dorchester Road, Frampton, Dorset, DT2 9NB, UK. No.3312883 VAT No. GB 744 6483 10

Copyright 1997-2008 - BioPortfolio Limited.