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Macronucleus

A macronucleus is the larger type of nucleus in ciliates. Macronuclei are polyploid and undergo direct division without mitosis. It controls the non-reproductive cell functions such as metabolism. During conjugation, the macronucleus disingtegrates, and a new macronucleus is formed by karyogamy of the micronuclei. The macronucleus contains hundreds of chromosomes, each present in ~50 copies. The macronucleus lacks a mechanism to precisely partition this complex genome equally during nuclear division; thus how the cell manages to maintain a balanced genome after generations of divisions is a mystery.Protozoan nucleus: the larger of two nuclei in most ciliate protozoans, involved in nonreproductive functions such as feeding and metabolismCategory:Organelles Macrophages (From the Wikpedia article Macronucleus.)

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Recent Publications on Macronucleus:

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C-5(6) sterol desaturase from tetrahymena thermophila: Gene identification and knockout, sequence analysis, and comparison to other C-5(6) sterol desaturases.
The gene coding for a C-5(6) sterol desaturase in Tetrahymena thermophila,...
11th November, 2009
Catedra de Biotecnologia y Microbiologia Industrial, Universidad de Buenos Eukaryot Cell. 2009 Aug;8(8):1287-97. Epub 2009 Jun 12.
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"Candidatus Paraholospora nucleivisitans", an intracellular bacterium in Paramecium sexaurelia shuttles between the cytoplasm and the nucleus of its host.
An intracellular bacterium was discovered in two isolates of Paramecium...
10th November, 2009
Universitat Stuttgart, Biologisches Institut, Pfaffenwaldring 57, 70569 Syst Appl Microbiol. 2009 Oct;32(7):490-500. Epub 2009 Aug 12.
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The presence of chimeric DNA consisting of 5' regions of the hemoglobin and nucleosome assembly protein-1 genes in Paramecium caudatum macronuclear genomic DNA.
We detected an unexpected small-sized DNA fragment during polymerase chain...
7th November, 2009
Department of Biological Science, Faculty of Science, Shizuoka University, Zoolog Sci. 2009 Apr;26(4):259-65.
PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements in the ciliate Paramecium tetraurelia.
Programmed genome rearrangements drive functional gene assembly in...
4th November, 2009
CNRS FRE 3144, Centre de Genetique Moleculaire, Gif-sur-Yvette F-91198 Genes Dev. 2009 Nov 1;23(21):2478-83.
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Subtraction by addition: domesticated transposases in programmed DNA elimination.
The ciliate Paramecium tetraurelia must eliminate approximately 60,000...
4th November, 2009
Biology Department, Washington University in St. Louis, St. Louis, Genes Dev. 2009 Nov 1;23(21):2455-60.
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Macronucleus Patents:

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US Patent No.Title
7060480 MRE11 orthologue and uses thereof
7202396 Rad3 orthologues and uses therof
7205453 Crop plant cystatin proteinase inhibitors encoding nucleic acids and methods of use
7214512 Genomic mammary Amyloid a sequence
7214852 Maize cellulose synthases encoding nucleic acids and uses thereof

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BioPortfolio Ltd. offers e-mail and postal lists for Macronucleus scientists - we have details of around 60 individuals working on Macronucleus .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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