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Macronucleus

A macronucleus is the larger type of nucleus in ciliates. Macronuclei are polyploid and undergo direct division without mitosis. It controls the non-reproductive cell functions such as metabolism. During conjugation, the macronucleus disingtegrates, and a new macronucleus is formed by karyogamy of the micronuclei. The macronucleus contains hundreds of chromosomes, each present in ~50 copies. The macronucleus lacks a mechanism to precisely partition this complex genome equally during nuclear division; thus how the cell manages to maintain a balanced genome after generations of divisions is a mystery.Protozoan nucleus: the larger of two nuclei in most ciliate protozoans, involved in nonreproductive functions such as feeding and metabolismCategory:Organelles Macrophages (From the Wikpedia article Macronucleus.)

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Recent Publications on Macronucleus:

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Nuclear localization of eukaryotic class II release factor (eRF3): implication for the multifunction of eRF3 in ciliates Euplotes cell.
Class II polypeptide release factor (eRF3), a ribosome and eRF1-dependent...
28th June, 2008
Institute of Biotechnology, Key Laboratory of Chemical Biology and Cell Biol Int. 2008 Mar;32(3):353-7. Epub 2008 Jan 9.
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Developmentally programmed DNA splicing in Paramecium reveals short-distance crosstalk between DNA cleavage sites.
Somatic genome assembly in the ciliate Paramecium involves the precise...
25th June, 2008
Ecole Normale Superieure, Laboratoire de Genetique Moleculaire, 75005 Nucleic Acids Res. 2008 Jun;36(10):3244-51. Epub 2008 Apr 17.
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Chromatin extrusion in resting encystment of Colpoda cucullus: a possible involvement of apoptosis-like nuclear death.
The extrusion of macronuclear chromatin is a remarkable characteristic...
13th June, 2008
Institute of Biological Science, Faculty of Science, Kochi University, Cell Biol Int. 2008 Jan;32(1):31-8. Epub 2007 Sep 4.
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The pathway to detangle a scrambled gene.
BACKGROUND: Programmed DNA elimination and reorganization frequently occur...
5th June, 2008
Institute of Cell Biology, University Witten/Herdecke, Witten, Germany. PLoS ONE. 2008 Jun 4;3(6):e2330.
DOI Direct Link
[Histone-antihistone interactions in the Escherichia coli-Tetrahymena pyriformis association]
Using the Escherichia coli-Tetrahymena pyriformis system, we revealed the...
5th June, 2008
Mikrobiologiia. 2008 Mar-Apr;77(2):219-25.

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Macronucleus Patents:

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US Patent No.Title
6943279 Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use
7057020 Isolated RuvB polypeptides
7060480 MRE11 orthologue and uses thereof
7070929 Genetic markers for improved disease resistance in animals (BPI)
7081518 Anti-mesothelin antibodies having high binding affinity

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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