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Malaria

Malaria is a vector-borne infectious disease caused by protozoan parasites. It is widespread in tropical and subtropical regions, including parts of the Americas, Asia, and Africa. Each year, it causes disease in approximately 515 million people and kills between one and three million people, the majority of whom are young children in Sub-Saharan Africa. Malaria is commonly associated with poverty, but is also a cause of poverty and a major hindrance to economic development.Malaria is one of the most common infectious diseases and an enormous public health problem. The disease is caused by protozoan parasites of the genus Plasmodium. Only four types of the plasmodium parasite can infect humans; the most serious forms of the disease are caused by Plasmodium falciparum and Plasmodium vivax, but other related species can also affect humans. This group of human-pathogenic Plasmodium species is usually referred to as malaria parasites.Malaria parasites are transmitted by female Anopheles mosquitoes. The parasites multiply within red blood cells, causing symptoms that include symptoms of anemia , as well as other general symptoms such as fever, chills, nausea, flu-like illness, and in severe cases, coma and death. Malaria transmission can be reduced by preventing mosquito bites with mosquito nets and insect repellents, or by mosquito control measures such as spraying insecticides inside houses and draining standing water where mosquitoes lay their eggs.Although some are under development, no vaccine is currently available for malaria; preventative drugs must be taken continuously to reduce the risk of infection. These prophylactic drug treatments are often too expensive for most people living in endemic areas. Most adults from endemic areas have a degree of long-term recurrent infection and also of partial resistance; the resistance reduces with time and such adults may become susceptible to severe malaria if they have spent a significant amount of time in non-endemic areas. They are strongly recommended to take full precautions if they return to an endemic area. Malaria infections are treated through the use of antimalarial drugs, such as quinine or artemisinin derivatives, although drug resistance is increasingly common. (From the Wikpedia article Malaria.)

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Recent Publications on Malaria:

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Artesunate for malaria.
Malakoplakia, typically involving the urinary tract, is an uncommon form...
19th July, 2008
N Engl J Med. 2008 Jul 17;359(3):313; author reply 314-5.
DOI Direct Link
Thymic alterations in Plasmodium berghei-infected mice.
The primary function of the thymus is to develop immature T-cells into...
19th July, 2008
Department of Microbiology and Immunology, Biology Institute, State Cell Immunol. 2008 Jul 15;.
DOI Direct Link
Topi, an IS630/Tc1/mariner-type transposable element in the African malaria mosquito, Anopheles gambiae.
IS630/Tc1/mariner elements are diverse and widespread within insects. The...
19th July, 2008
Center for Biosystems Research; University of Maryland Biotechnology Gene. 2008 Jun 26;.
DOI Direct Link
Nutrient content of diet affects the signaling activity of the insulin/target of rapamycin/p70 S6 kinase pathway in the African malaria mosquito Anopheles gambiae.
Regulation of female mosquito feeding and reproduction plays a central...
19th July, 2008
Laboratory of Animal Physiology, Institute of Biology, University of J Insect Physiol. 2008 Jun 26;.
DOI Direct Link
The effect of water turbidity on the near-surface water temperature of larval habitats of the malaria mosquito Anopheles gambiae.
Water temperature is an important determinant in many aquatic biological...
18th July, 2008
Meteorology and Air Quality, Wageningen University, Wageningen, The Int J Biometeorol. 2008 Jul 17;.
DOI Direct Link

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BioNews Results for Malaria:

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Indian firms, Clinton Foundation sign deal on malaria drugs
NetIndia123.com:  Jul 19 2008 1:51AM Matching: malaria
Gene Mutation That Protects Against Virtually Extinct Form of Malaria Makes Blacks More Susceptible to HIV, St
The Body:  Jul 18 2008 11:42PM Matching: malaria
Bill Clinton taps Indian pharma
Financial Express:  Jul 19 2008 2:19AM Matching: malaria
Anti-malaria gene in Africans raises HIV risk
Turkish Press:  Jul 19 2008 2:46AM Matching: malaria
Clinton taps 4 Indian drug firms
Business Standard India:  Jul 18 2008 11:16PM Matching: malaria
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Malaria Clinical Trials:

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PALUREA: Severe Imported Malaria in Adults
Malaria Interventions: Genetic: with severe malaria hospitalized in ICU;   Genetic: with uncomplicated malaria

Malaria Patents:

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US Patent No.Title
7385032 Bimer or an oligomer of a dimer, trimer, quadromer or pentamer of recombinant fusion proteins
7390483 Universal GM-CSF expressing bystander human K562 cell line
7390619 Optimization of immunomodulatory properties of genetic vaccines
7390626 Methods and kit for diagnosing tick borne illnesses
7390637 Keratinocyte derived interferon

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Companies working in the area of Malaria from Bioportfolio's Biocorporate database :

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Company Name

GenVec

GenVec, Inc. (NASDAQ: GNVC) is a biopharmaceutical company developing novel gene-based therapeutic drugs and vaccines. Each of our gene-based therapeutic product candidates use a common patent...
www.genvec.com/        View full profile
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CEL-SCI Corporation

CEL-SCI Corporation is involved in the research and development of certain drugs and vaccines. CEL-SCI's first product, MULTIKINE(TM), manufactured using the Company's proprietary cell...
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Cenix BioScience GmbH

Cenix BioScience GmbH is a pioneer and global leader in the convergence of high throughput (HT), genomics-driven applications of RNA interference (RNAi) with high content, multi-parametric cell...
www.cenix-bioscience.com/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Malaria scientists - we have details of around 4663 individuals working on Malaria .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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