Recent Publications on Map Kinase Kinase Kinase 1: |  |
Mitogen-activated protein kinase kinase kinase 1 protects against nickel-induced acute lung injury.
Nickel compounds are environmental and occupational hazards that pose...
Direct Link | 30th August, 2008
| Department of Environmental Health and Center of Environmental Genetics,
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Interfering with cellular signaling pathways enhances sensitization to combined sodium butyrate and GCV treatment in EBV-positive tumor cells.
The combination of sodium butyrate (NaB) and ganciclovir (GCV) was...
Direct Link | 30th August, 2008
| Center of Microbiology, Biochemistry, and Pharmacology, School of
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Cell signaling. "Make and brake" in signaling.
Saturated free fatty acid (FFA) is a major source of metabolic stress that...
Direct Link | 14th August, 2008
| University of Crete Medical School and Institute for Molecular Biology and
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Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.
Cytokine signaling is thought to require assembly of multicomponent...
Direct Link | 14th August, 2008
| Laboratory of Gene Regulation and Signal Transduction, Department of
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JNK/c-Jun signaling mediates an anti-apoptotic effect of RANKL in osteoclasts.
INTRODUCTION: RANKL is known to be important not only for differentiation...
Direct Link | 13th August, 2008
| Department of Biochemistry, Osaka University Graduate School of Dentistry,
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The MAPK kinase kinase-1 is essential for stress-induced pancreatic islet cell death.
The aim of the present investigation was to characterize the role of the...
Direct Link | 9th August, 2008
| Department of Medical Cell Biology, Uppsala University, Biomedicum, S-751
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MAPK kinase kinase-1 is essential for cytokine-induced c-Jun NH2-terminal kinase and nuclear factor-kappaB activation in human pancreatic islet cells.
OBJECTIVE: The transcription factor nuclear factor-kappaB (NF-kappaB) and...
Direct Link | 2nd August, 2008
| Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
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Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBPbeta-dependent pathway.
Shear stress is a pathophysiologically relevant mechanical signal in...
Direct Link | 1st August, 2008
| Department of Chemical and Biomolecular Engineering, The Johns Hopkins
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DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death.
DJ-1 is a multifunctional protein that performs functions in...
Direct Link | 29th July, 2008
| Hormone Research Center, School of Biological Sciences and Technology,
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Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment.
Tumour necrosis factor related apoptosis inducing ligand (TRAIL) binds to...
Direct Link | 10th July, 2008
| Manitoba Institute of Cell Biology, University of Manitoba, 675 McDermot
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Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics.
A three-stage genome-wide association study recently identified single...
Direct Link | 13th June, 2008
| Division of Cancer Epidemiology and Genetics, National Cancer Institute,
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G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.
In Drosophila, activation of Jun N-terminal Kinase (JNK) mediated by...
Direct Link | 22nd May, 2008
| Department of Pharmacology, Health Sciences Center, State University of
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Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers.
Germline mutations in BRCA1 and BRCA2 confer high risks of breast cancer....
Direct Link | 14th May, 2008
| Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health
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Clonal selection in malignant transformation of human fibroblasts transduced with defined cellular oncogenes.
Recent evidence has implied that disruption of a limited number of defined...
Direct Link | 9th April, 2008
| Department of Oncological Sciences, Mount Sinai School of Medicine, New
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