Recent Publications on Map Kinase Kinase Kinase 4: |  |
G alpha o mediates WNT-JNK signaling through dishevelled 1 and 3, RhoA family members, and MEKK 1 and 4 in mammalian cells.
In Drosophila, activation of Jun N-terminal Kinase (JNK) mediated by...
Direct Link | 22nd May, 2008
| Department of Pharmacology, Health Sciences Center, State University of
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Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex.
Postmitotic cortical neurons that fail to initiate migration can remain...
Direct Link | 16th May, 2008
| Department of Neurobiology and Kavli Institute of Neuroscience, Yale
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MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
The MAPK kinase kinase MEKK4 is required for neurulation and skeletal...
Direct Link | 13th December, 2007
| Department of Pharmacology and the Lineberger Comprehensive Cancer Center,
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Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia.
Identification of the signalling cascades that are differentially...
Direct Link | 18th September, 2007
| Department of Pathology, University of Chicago, Chicago, IL, USA.
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Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells.
Valproic acid (VPA), a mood stabilizer and anticonvulsant, has a variety...
Direct Link | 27th June, 2007
| Department of Pharmacology, National Research Institute for Child Health
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The MEK kinases MEKK4/Ssk2p facilitate complexity in the stress signaling responses of diverse systems.
The mammalian JNK/p38 MAP kinase kinase kinase MEKK4 and the Saccharomyces...
Direct Link | 7th June, 2007
| Department of Biochemistry and Molecular Biology, SUNY Upstate Medical
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Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain.
The mitogen-activated protein kinase (MAPK) module, composed of a MAPK, a...
Direct Link | 1st May, 2007
| Institute of Medical Sciences, The University of Tokyo, 4-6-1
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Stress-associated MAP kinase fills in the map of filamin-mediated neuronal migration.
The mitogen-activated protein kinase (MAPK) module, composed of a MAPK, a...
Direct Link | 17th February, 2007
| Department of Biochemistry, Institute of Medical Science, University of
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MEKK4 regulates developmental EMT in the embryonic heart.
Congenital heart malformations occur at a rate of one per one hundred...
Direct Link | 24th January, 2007
| Department of Pharmacology and Toxicology, College of Pharmacy, The
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The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages.
The role of H2O2 as a second messenger in signal transduction pathways is...
Direct Link | 12th January, 2007
| School of Natural Sciences, University of California Merced, Merced, CA
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MEKK4 signaling regulates filamin expression and neuronal migration.
Periventricular heterotopia (PVH) is a congenital malformation of human...
Direct Link | 11th January, 2007
| Department of Neurobiology and Kavli Institute of Neuroscience, Yale
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MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells.
Mitogen-activated protein kinase (MAPK) cascades contain a trio of...
Direct Link | 27th October, 2006
| Renal Section, Department of Medicine, Baylor College of Medicine,
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D-MEKK1, the Drosophila orthologue of mammalian MEKK4/MTK1, and Hemipterous/D-MKK7 mediate the activation of D-JNK by cadmium and arsenite in Schneider cells.
BACKGROUND: The family of c-Jun NH2-terminal kinases (JNK) plays important...
Direct Link | 4th March, 2006
| Department of Cell and Developmental Biology, Oregon Health & Science
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CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.
CIN85 is a multi-adaptor protein involved in different cellular functions...
Direct Link | 13th January, 2006
| INSERM, U.624, 13288 Marseille, France.
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Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.
Skeletal disorders and neural tube closure defects represent clinically...
Direct Link | 13th December, 2005
| Department of Pharmacology, University of North Carolina, Chapel Hill,
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