Nephrocalcinosis

Nephrocalcinosis, once known as Albright's calcinosis after Fuller Albright, is a term originally used to describe deposition of calcium salts in the renal parenchyma due to hyperparathyroidism. It is now more commonly used to describe diffuse, fine, renal parenchymal calcification on radiology. During its early stages, nephrocalcinosis is visible on x-ray, and appears as a fine granular mottling over the renal outlines. These outlines eventually come together to form a dense mass.It is most commonly seen as an incidental finding with medullary sponge kidney on an abdominal x-ray.However, it may be severe enough to cause renal tubular acidosis or even end stage renal failure, due to disruption of the renal tissue by the deposited calcium. (From the Wikpedia article Nephrocalcinosis.)

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Recent Publications on Nephrocalcinosis:
The origin of nephrocalcinosis, Randall's plaque and renal stones: a cell biology viewpoint. Medullary nephrocalcinosis is a rare condition typically observed in...	17th November, 2009	Division of Nephrology, Renal Program, Catholic University Hospital, Rome,	Arch Ital Urol Androl. 2009 Sep;81(3):166-70.
Nephrocalcinosis. Medullary nephrocalcinosis is a rare condition typically observed in...	23rd October, 2009	James Buchanan Brady Urological Institute and The Russell H. Morgan	J Urol. 2009 Dec;182(6):2910-1. Epub 2009 Oct 28. DOI Direct Link
[Long term renal outcome of children born preterm: a regular follow-up is needed] Most of the published studies evaluating renal prognosis of children born...	20th October, 2009	Centre de Reference des Maladies Renales Rares, Service de Nephrologie et	Arch Pediatr. 2009 Sep;16 Suppl 1:S42-8. DOI Direct Link
Medullary sponge kidney presenting in a neonate with distal renal tubular acidosis and failure to thrive: a case report. INTRODUCTION: Medullary sponge kidney is a congenital anomaly...	16th October, 2009		J Med Case Reports. 2009 Apr 29;3:6656. DOI Direct Link
Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/type IIc sodium-phosphate cotransporter: presentation as hypercalciuria and nephrolithiasis. CONTEXT: Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is...	13th October, 2009	Cleveland Clinic Lerner College of Medicine at Case Western Reserve	J Clin Endocrinol Metab. 2009 Nov;94(11):4433-8. Epub 2009 Oct 9. DOI Direct Link
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Nephrocalcinosis Patents:
US Patent No.	Title
7091315	Protein HDPBQ71
7238660	Albumin fusion proteins
7238667	Albumin fusion proteins
7241585	14171 protein kinase, a novel human protein kinase and uses thereof
7256010	Nucleic acid sequences encoding melanoma associated antigen molecules, aminotransferase molecules, ATPase molecules, acyltransferase molecules, pyridoxal-phosphate dependant enzyme molecules and uses therefor
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