Nesidioblastosis

Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive function of pancreatic beta cells with an abnormal microscopic appearance. The term was coined in the first half of the 20th century. The abnormal histologic aspects of the tissue included the presence of islet cell enlargement, islet cell dysplasia, beta cells budding from ductal epithelium, and islets in apposition to ducts.By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1970s, it was used as a synonym for what is now referred to as congenital hyperinsulinism. Most congenital hyperinsulinism is caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features were sometimes seen in pancreatic tissue from normal infants and even adults, and is not consistently associated with hyperinsulinemic hypoglycemia. However, the term has been resurrected in recent years to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery. (From the Wikpedia article Nesidioblastosis.)

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Recent Publications on Nesidioblastosis:
[Nesidioblastosis in an adult with type 2 diabetes mellitus: A case report.] Adults-onset nesidioblastosis, as a differential diagnosis of organic...	16th October, 2009	Department of endocrinology, Peking University First Hospital, Beijing	Beijing Da Xue Xue Bao. 2009 Oct 18;41(5):590-2.
Bariatric surgery: unstressing or boosting the beta-cell? Bariatric surgery is the most effective therapy for severe obesity in...	13th October, 2009	Department of Internal Medicine, Catholic University, Rome, Italy.	Diabetes Obes Metab. 2009 Nov;11 Suppl 4:130-42. DOI Direct Link
Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. In adults, nesidioblastosis is a very infrequent condition and a rare...	9th October, 2009	Royal Brisbane and Women's Hospital, Butterfield Street, Herston,	Ann Nucl Med. 2009 Jul;23(5):497-9. Epub 2009 Apr 22. DOI Direct Link
Correlation of Pancreatic Histopathologic Findings and Islet Yield in Children With Chronic Pancreatitis Undergoing Total Pancreatectomy and Islet Autotransplantation. OBJECTIVES:: The probability of insulin independence after intraportal...	12th September, 2009	From the Departments of *Surgery, daggerPathology, double	Pancreas. 2009 Sep 8. DOI Direct Link
A 20-year-old man with recurrent abdominal pain and vomiting since the age of 5 years. Familial chronic pancreatitis with nesidioblastosis and hyperinsulinaemic hypoglycaemia. OBJECTIVES:: The probability of insulin independence after intraportal...	21st August, 2009	Sir Ganga Ram Hospital, New Delhi.	Natl Med J India. 2008 Nov-Dec;21(6):307-12.
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Nesidioblastosis Patents:
US Patent No.	Title
6864234	Somatostatin agonists
6969727	Heterocyclic aromatic compounds useful as growth hormone secretagogues
6992102	Bicyclic modulators of androgen receptor function
7001911	Fused cyclic modulators of nuclear hormone receptor function
7022677	Amide derivatives as growth hormone secretagogues
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