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NeuroblastomaNeuroblastoma is the most common extracranial solid cancer in infancy and childhood, with an annual incidence of about 650 new cases per year in the US. Close to 50 percent of neuroblastoma cases occur in children younger than two years old. It is a neuroendocrine tumor, arising from any neural crest element of the sympathetic nervous system or SNS. A branch of the autonomic nervous system, the SNS is a nerve network that carries messages from the brain throughout the body and is responsible for the fight-or-flight response and production of adrenaline or epinephrine. Its solid tumors, which take the form of a lump or mass, commonly begin in one of the adrenal glands, though they can also develop in nerve tissues in the neck, chest, abdomen, or pelvis. The cause of neuroblastoma is unknown, though most physicians believe that it is an accidental cell growth that occurs during normal development of the adrenal glands.Neuroblastoma is one of the rare human malignancies known to demonstrate spontaneous regression from an undifferentiated state to a completely benign cellular appearance. (From the Wikpedia article Neuroblastoma.) Download PDF containing detailed information.
Recent Publications on Neuroblastoma: |  |
Kinetics of a Novel Isoform of Phosphate Activated Glutaminase (PAG) in SH-SY5Y Neuroblastoma Cells.
We have recently found that the neuroblastoma cell line SH-SY5Y expresses... | 7th November, 2009
| Department of Biochemistry, Neurochemical Section, Institute of Basic
| Neurochem Res. 2009 Oct 27.
DOI Direct Link |
BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.
Bcl-2 family proteins regulate mitochondrial apoptosis downstream of... | 7th November, 2009
| [1] Division of Oncology, The Children's Hospital of Philadelphia, 3615
| Cell Death Differ. 2009 Nov 6.
DOI Direct Link |
The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development.
Mutations in the gene encoding FERM domain-containing 7 protein (FRMD7)... | 7th November, 2009
| MRC Toxicology Unit, University of Leicester, Leicester, LE1 9HN, UK.
| Hum Mol Genet. 2009 Nov 5.
DOI Direct Link |
Compartmental intrathecal radioimmunotherapy: results for treatment for metastatic CNS neuroblastoma.
Innovation in the management of brain metastases is needed. We evaluated... | 6th November, 2009
| Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, 1275
| J Neurooncol. 2009 Nov 5.
DOI Direct Link |
Docosahexaenoic acid metabolome in neural tumors: identification of cytotoxic intermediates.
Docosahexaenoic acid (DHA) protects neural cells from stress-induced... | 6th November, 2009
| *Childhood Cancer Research Unit, Department of Woman and Child Health,
| FASEB J. 2009 Nov 4.
DOI Direct Link |
→View more research publications. |
Press Releases About Neuroblastoma:
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| Reportlinker Adds World Market for Cancer Therapeutics and Biotherapeutics, 3rd. Edition, The Report |
24th September, 2009 |
Reportlinker |
-- SERMS
The report includes market share by type of cancer and market share by company for each of the three major segments. It also includes statistical information for cancers by type
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| Bayer Announces Leukine(R) Data Presentations at 45th American Society of Clinical Oncology (ASCO) Annual Meeting |
29th May, 2009 |
Bayer Healthcare Pharmaceuticals Inc. |
WAYNE, N.J., May 29 /PRNewswire/ -- Bayer Healthcare Pharmaceuticals Inc. today announced that several studies evaluating the use of Leukine(R) (sargramostim) will be presented at the 2009 American
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| New Therapy Enlists Immune System to Boost Cure Rate in a Childhood Cancer |
28th May, 2009 |
The Children's Hospital of Philadelphia |
--In a First, Immunotherapy Works Against Neuroblastoma--
PHILADELPHIA, May 28 /PRNewswire-USNewswire/ -- A multicenter research team has announced encouraging results for an experimental therapy
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| Drilling Engineers Donate $35,000 to Texas Children's Hospital |
15th December, 2008 |
American Association of Drilling Engineers |
HOUSTON, Dec. 15 /PRNewswire/ -- The Houston Chapter of the American
Association of Drilling Engineers (AADE) recently presented Texas Children's
Hospital with a donation of $35,000 to
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| Scripps Translational Science Institute Contributes to Discovery of Predisposition Gene for Childhood Cancer |
25th August, 2008 |
Scripps Translational Science Institute |
SAN DIEGO, Aug. 25 /PRNewswire/ -- Researchers at Scripps Translational
Science Institute (STSI) have contributed to a major genetic breakthrough --
the discovery of a gene responsible for the
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BioPortfolio Ltd. offers e-mail and postal lists for Neuroblastoma scientists - we have details of around 2508 individuals working on Neuroblastoma .
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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
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