Recent Publications on O6-Methylguanine-DNA Methyltransferase: |  |
The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity.
First-line therapy for patients with glioblastoma multiforme (GBM)...
Direct Link | 25th September, 2008
| UCLA Neuro-Oncology Program, Department of Neurology, David Geffen School
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Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.
Epigenetic silencing of the DNA repair protein O(6)-methylguanine-DNA...
Direct Link | 23rd September, 2008
| OncoMethylome Sciences SA, Tour 5 GIGA (B34), +3, Avenue de l'Hopital 11,
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Aberrant MGMT (O6-methylguanine-DNA methyltransferase) promoter methylation in choroid plexus tumors.
Aberrant methylation of the MGMT (O6-methylguanine-DNA methyltransferase)...
Direct Link | 17th September, 2008
| Institute of Neuropathology, University Hospital Munster, Domagkstr. 19,
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Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells.
Retroviral-mediated delivery of the P140K mutant O(6)-methylguanine-DNA...
Direct Link | 9th September, 2008
| Division of Experimental Hematology, Cincinnati Children's Hospital
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Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells.
O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein...
Direct Link | 23rd August, 2008
| National Institute of Cancer Research, National Health Research
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| Individual adjuvant therapy for malignant gliomas based on O6-methylguanine-DNA methyltransferase messenger RNA quantitation by real-time reverse-transcription polymerase chain-reaction.
| 22nd August, 2008
| Department of Neurosurgery, Kawasaki Hospital, Ibaraki 313-8511, Japan.
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Careful exclusion of non-neoplastic brain components is required for an appropriate evaluation of O6-methylguanine-DNA methyltransferase status in glioma: relationship between immunohistochemistry and methylation analysis.
Evaluation of O6-methylguanine-DNA methyltransferase (MGMT) expression is...
Direct Link | 15th August, 2008
| Laboratory of Molecular and Cellular Pathology, Hokkaido University
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| Relevance of MSP assay for the detection of MGMT promoter hypermethylation in glioblastomas.
| 13th August, 2008
| Department of Neurological Surgery, Nihon University School of Medicine,
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Different initial steps of apoptosis induced by two types of antineoplastic drugs.
O6-Methylguanine and O6-chloroethylguanine are primary DNA lesions...
Direct Link | 5th August, 2008
| Frontier Research Center, Fukuoka Dental College, 2-15-1, Tamura,
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| O6-Methylguanine-DNA-methyltransferase in recurring anaplastic ependymomas: PCR and immunohistochemistry.
| 22nd July, 2008
| Department of Human Pathology and Oncology, University of Florence,
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Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation.
The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT)...
Direct Link | 14th June, 2008
| Department of Pharmacology and Toxicology, Faculty of Medicine, University
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A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.
The O(6)-methylguanine DNA methyltransferase (MGMT) gene encodes a DNA...
Direct Link | 13th June, 2008
| Department of Anatomy, University of Kiel, Olshausenstr. 40, 24098 Kiel,
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An O6-methylguanine-DNA methyltransferase-like protein from Thermus thermophilus interacts with a nucleotide excision repair protein.
The major damage to DNA caused by alkylating agents involves the formation...
Direct Link | 17th May, 2008
| Department of Biological Sciences, Graduate School of Science, Osaka
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Survival and tumorigenesis in O6-methylguanine DNA methyltransferase-deficient mice following cyclophosphamide exposure.
O(6)-methylguanine DNA methyltransferase (MGMT) deficiency is associated...
Direct Link | 15th May, 2008
| Department of Pediatrics, University of Chicago, 5841 S. Maryland Avenue,
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Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker.
Silencing of O6-methylguanine-DNA methyltransferase (MGMT) protein...
Direct Link | 11th April, 2008
| Department of Internal Medicine 1, Medial University of Vienna, Vienna,
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