Ochronosis

Ochronosis, often called alkaptonuric ochronosis, is an autosomal recessive metabolic disorder that causes an excess of homogentisic acid, resulting in adverse pigmentation, calcification, and inflammation of cartilagenous and related tissue throughout the body. The disorder is a result of incomplete metbolism of homogentisic acid, tyrosine and phenylalanine. The face, skeletal system, cardiovascular system, respiratory system, urinary system and to a lesser degree, the skin, are affected by this disease. (From the Wikpedia article Ochronosis.)

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Recent Publications on Ochronosis:
Hydroquinone-induced exogenous ochronosis in Chinese--two case reports and a review. Ochronosis is a rare metabolic disease caused by the deficiency of the...	26th June, 2008		Int J Dermatol. 2008 Jun;47(6):639-40. DOI Direct Link
[Anesthesia in a patient with alkaptonuric ochronosis for total hip arthroplasty] Alkaptonuric ochronosis, caused by a deficiency of homogentisate...	25th June, 2008	Department of Anesthesiology, Kyushu Rosai Hospital, Kitakyushu 800-0296.	Masui. 2008 Apr;57(4):439-42.
Ochronosis, arthroscopy of a black knee: a case report and review of the literature. Ochronotic arthropathy is a rare condition found in patients with...	25th June, 2008	Department of Orthopaedic Surgery and Traumatology, Algemeen Stedelijk	Knee Surg Sports Traumatol Arthrosc. 2008 Feb;16(2):182-4. Epub 2007 Sep DOI Direct Link
[Arthroplasty for the treatment of joint degeneration caused by ochronosis in two cases.] Ochronosis is a rare metabolic disease caused by the deficiency of the...	17th June, 2008	Department of Pathology (Patoloji Anabilim Dali), Medicine Faculty of	Acta Orthop Traumatol Turc. 2008;42(2):139-144.
Aortic valve stenosis due to alkaptonuria. Cardiovascular disease is a less-well appreciated aspect of alkaptonuria....	21st May, 2008	Department of Cardiology, Hospital of Wetzlar, Wetzlar, Geramny.	J Heart Valve Dis. 2008 Jan;17(1):127-9.
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Ochronosis Clinical Trials:
Study of Alkaptonuria
Long-Term Study of Nitisinone to Treat Alkaptonuria	Alkaptonuria Intervention: Drug: Nitisinone (NTBC)

Ochronosis Patents:
US Patent No.	Title
7359748	Apparatus for total immersion photography
5326569	Medical foods for the nutritional support of child/adult metabolic diseases
5368841	Photodynamic therapy for the destruction of the synovium in the treatment of rheumatoid arthritis and the inflammatory arthritides
5550146	Medical foods for the nutritional support of infant/toddler metabolic diseases
5587399	Method for preparing medical foods for the nutritional support of infants/toddlers with metabolic diseases
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