Ochronosis

Ochronosis, often called alkaptonuric ochronosis, is an autosomal recessive metabolic disorder that causes an excess of homogentisic acid, resulting in adverse pigmentation, calcification, and inflammation of cartilagenous and related tissue throughout the body. The disorder is a result of incomplete metbolism of homogentisic acid, tyrosine and phenylalanine. The face, skeletal system, cardiovascular system, respiratory system, urinary system and to a lesser degree, the skin, are affected by this disease. (From the Wikpedia article Ochronosis.)

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Recent Publications on Ochronosis:
Joint and tendineous involvement in ochronosis: clinical history and imaging of a case. We describe a case of a previously healthy 35-year-old man who presents...	13th November, 2009		Clin Exp Rheumatol. 2009 Jul-Aug;27(4):696-7.
Melasma in Latin America: options for therapy and treatment algorithm. OBJECTIVE/AIM: To examine approaches to therapy for melasma in Latin...	3rd November, 2009	University of Rio Grande do Sul, Hospital de Clinicas de Porto Alegre,	J Eur Acad Dermatol Venereol. 2009 Jul;23(7):760-72. DOI Direct Link
Skin bleaching: highlighting the misuse of cutaneous depigmenting agents. Hydroquinone and other cutaneous depigmenting agents are widely used by...	3rd November, 2009	Department of Dermatology, Chelsea and Westminster Hospital, London, UK.	J Eur Acad Dermatol Venereol. 2009 Jul;23(7):741-50. Epub 2009 Mar 11. DOI Direct Link
Mutation spectrum of homogentisic acid oxidase (HGD) in alkaptonuria. Alkaptonuria (AKU) is a rare autosomal recessive metabolic disorder,...	29th October, 2009	Medical Genetics Branch, National Human Genome Research Institute,	Hum Mutat. 2009 Sep 4. DOI Direct Link
Comparative study on low back pain misdiagnosed as spondyloarthropathy. This study aims to investigate features of different diseases with low...	14th October, 2009	Department of Rheumatology and Immunology, Peking University Third	Clin Rheumatol. 2009 Aug;28(8):893-8. Epub 2009 May 17. DOI Direct Link
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Ochronosis Patents:
US Patent No.	Title
7528153	Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors
6231343	Method for bleaching discolored tooth by titanium dioxide photocatalyst
6118050	Hydroxyphenylpyruvate dioxygenase gene from arabidopsis and method of screening for inhibitors thereof
6017960	Method of treating post-inflammatory hyperpigmentation in black skin with a retinoid, and method of lightening black skin with a retinoid
5750570	Method of treatment of hyperpigmentation in black skin with retinoic acid and method of lightening black skin with retinoic acid
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