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P38 Mitogen-Activated Protein Kinases

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Recent Publications on P38 Mitogen-Activated Protein Kinases:

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Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK).
The observation that genistein may behave as a pro-oxidant agent lead us...
19th July, 2008
Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Int J Cancer. 2008 Sep 1;123(5):1205-14.
DOI Direct Link
Effect of A2B adenosine receptor gene ablation on proinflammatory adenosine signaling in mast cells.
Pharmacological studies suggest that A(2B) adenosine receptors mediate...
19th July, 2008
Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt. J Immunol. 2008 Jun 1;180(11):7212-20.
PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils.
Neutrophils encounter and 'prioritize' many chemoattractants in their...
17th July, 2008
Institute of Infection and Immunity, University of Calgary, Calgary T2N Nat Immunol. 2008 Jul;9(7):743-52. Epub 2008 Jun 8.
DOI Direct Link
Mcl-1 is regulated by IL-6 and mediates the survival activity of the cytokine in a model of late stage prostate carcinoma.
The proinflammatory cytokine interleukin-6 (IL-6) has been considered a...
11th July, 2008
Department of Urology, Innsbruck Medical University, Anichstrasse, Adv Exp Med Biol. 2008;617:547-55.
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
There is increasing evidence for a role of somatic cellular senescence in...
9th July, 2008
Division of Pediatric Nephrology, University Children's Hospital, Hypertension. 2008 Jul;52(1):123-9. Epub 2008 May 26.
DOI Direct Link

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P38 Mitogen-Activated Protein Kinases Clinical Trials:

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p38 Mitogen−Activated Protein Kinase (MAPK) and Steroid Insensitivity in Asthma
Asthma Intervention: Other: Fiberoptic bronchoscopy; blood test

P38 Mitogen-Activated Protein Kinases Patents:

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US Patent No.Title
7361633 Screening method and anti-tumor drug candidate obtained therefrom
7259000 Polynucleotides encoding chimeric chemokine receptors
7195902 Phosphatases which activate map kinase pathways
6972298 Method of treating or inhibiting neutrophil chemotaxis by administering a MEK inhibitor
6924415 Transgenic mice comprising a constitutively-activated MEK5 and exhibiting cardiac hypertrophy and dilated cardiomyopathy

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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