Parasitemia

Parasitemia is the quantitative content of parasites in the blood. It is used as a measurement of parasite load in the organism and an indication of the degree of an active parasitic infection. Systematic measurement of parasitemia is important in many phases of the assessment of disease, such as in diagnosis and in the follow-up of therapy, particularly in the chronic phase, when cure depends on ascertaining a parasitemia of zero.The methods to be used for quantifying parasitemia depends on the parasitic species and its life cycle. For instance, in malaria, the number of plasmodia can be counted using an optical microscope, on a special thick film or thin film blood smear .The use of molecular biology techniques, such as PCR has been more and more used as a tool to measure parasitemia, specially in patients in the chronic phase of disease. In this technique, blood samples are obtained from the patient, and specific DNA of the parasite is extracted and amplified by PCR. Category:Parasitology Parasitic (From the Wikpedia article Parasitemia.)

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Recent Publications on Parasitemia:
Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on Genotypes of P. falciparum in Adults Participating in a Malaria Vaccine Clinical Trial. OBJECTIVE: RTS,S, a candidate vaccine for malaria, is a recombinant...	20th November, 2009	Walter Reed Project, Kenya Medical Research Institute, Kisumu, Kenya.	PLoS One. 2009 Nov 17;4(11):e7849. DOI Direct Link
{alpha}-Tocopherol transfer protein inhibition is effective in the prevention of cerebral malaria in mice. BACKGROUND: Nutritional status likely plays an important role in...	20th November, 2009	Research Unit for Functional Genomics, National Research Center for	Am J Clin Nutr. 2009 Nov 18. DOI Direct Link
Successful sporozoite challenge model in human volunteers with Plasmodium vivax strain derived from human donors. Successful establishment of a Plasmodium vivax sporozoite challenge model...	18th November, 2009	Instituto de Inmunologia, Universidad del Valle, Cali, Colombia.	Am J Trop Med Hyg. 2009 Nov;81(5):740-6. DOI Direct Link
Heroes or villains? T regulatory cells in malaria infection. Infection with Plasmodium parasites can cause severe disease due to a lack...	17th November, 2009	Department of Immunology, Monash University, Alfred Medical Research and	Trends Parasitol. 2009 Nov 12. DOI Direct Link
Accelerated clearance of Plasmodium-infected erythrocytes in sickle cell trait and annexin-A7 deficiency. The course of malaria does not only depend on the virulence of the...	17th November, 2009	Department of Physiology, University of Tubingen, Germany.	Cell Physiol Biochem. 2009;24(5-6):415-28. Epub 2009 Nov 4. DOI Direct Link
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Parasitemia Patents:
US Patent No.	Title
7303883	Diagnosis of parasites
7407661	Methods and reagents that generate a CD8 T cell immune response
7417156	Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers
7423181	Aminoalkoxy-functional chalcones
7427483	Utilization of nucleotide probes in ELISA procedure for the quantitative determination of Plasmodium falciparum DNA in malaria
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