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Phenotype

species Donax variabilis show diverse coloration and patterning in their phenotypes.A phenotype describes any observed quality of an organism, such as its morphology, development, or behavior, as opposed to its genotype - the inherited instructions it carries, which may or may not be expressed. This genotype-phenotype distinction was proposed by Wilhelm Johannsen in 1911 to make clear the difference between an organism's heredity and what that heredity produces. The distinction is similar to that proposed by August Weismann, who distinguished between germ plasm and somatic cells . A more modern version is Francis Crick's Central dogma of molecular biology.Despite its seemingly straightforward definition, the concept of the phenotype has some hidden subtleties. In the first place, most of the molecules and structures coded by the genetic material are not visible in the appearance of an organism, yet are part of the phenotype. Human blood groups are an example. Therefore, by extension, the term phenotype must include characteristics that can be made visible by some technical procedure. A further, and more radical, extension would add inherited behaviour to the phenotype.Second, the phenotype is not simply a product of the genotype, but is influenced by the environment to a greater or lesser extent . And, further, if the genotype is defined narrowly, then it must be remembered that not all heredity is carried by the nucleus. Mitochondria, for example, divide in unison with the nucleus, but transmit their own DNA directly, not via the nucleus.The phenotype is composed of traits or characteristics . Some phenotypes are controlled entirely by the individual's genes. Others are controlled by genes but are significantly affected by extragenetic or environmental factors. Almost all humans inherit the capacity to speak and understand language, but which language they learn is entirely an environmental matter. (From the Wikpedia article Phenotype.)

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Recent Publications on Phenotype:

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Megacell phenotype and its relation to metabolic alterations in transketolase deficient strain of Bacillus pumilus.
Fermentation with transketolase (tkt) deficient strain of Bacillus is the...
29th November, 2008
School of Biosciences and Bioengineering, Indian Institute of Technology Biotechnol Bioeng. 2008 Oct 30.
DOI Direct Link
Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.
We examined TCR:MHC/peptide interactions and in vivo epitope availability...
29th November, 2008
Department of Biotechnology Engineering, Ort Braude College, Karmiel, Eur J Immunol. 2008 Nov 27;38(12):3339-3353.
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Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3.
FOXP3 is required for the development of Treg and its expression is often...
29th November, 2008
Department of Surgery, University of British Columbia, Vancouver, Canada. Eur J Immunol. 2008 Nov 27;38(12):3282-3289.
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In this issue.
COVER IMAGE: The cover image depicts IgG immunostaining in kidney...
29th November, 2008
Eur J Immunol. 2008 Nov 27;38(12):3252-3253.
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Impact of molecularly defined hypolactasia, self-perceived milk intolerance and milk consumption on bone mineral density in a population sample in Northern Europe.
Objective. Milk intake as a source of calcium is considered an important...
29th November, 2008
Department of Internal Medicine, University of Tartu, Tartu, Estonia. Scand J Gastroenterol. 2008 Nov 27:1-7.
DOI Direct Link

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BioNews Results for Phenotype:

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Richer earns Department of Defense research award
Denver's Nursing Star:  Nov 19 2008 1:29PM Matching: phenotype
Infants with chronic neonatal lung disease: recommendations for the use of home oxygen therapy
The Medical Journal of Australia:  Nov 16 2008 12:42PM Matching: phenotype
Biolog Announces Successes in Analysis and Identification of Mycobacterium, Nocardia, and other Pathogenic Bac
Pharma Live:  Nov 14 2008 7:56PM Matching: phenotype
Biolog Announces Successes in Analysis and Identification of Mycobacterium, Nocardia, and other Pathogenic Bac
DiGiTAL50:  Nov 14 2008 7:48AM Matching: phenotype
New clinical study will help doctors assess abnormal bleeding
News-Medical.Net:  Nov 3 2008 11:30PM Matching: phenotype
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Phenotype Clinical Trials:

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Study of Factors of Genetic Susceptibility Associated to Severe Caries Phenotype
Dental Caries

Phenotype Patents:

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US Patent No.Title
7456348 Inbred maize line PHEWW
7456335 Nucleic acid sequences and their use in methods for achieving pathogen resistance in plants
7456334 Maize Cr1bio gene promoter and its use to direct root-preferred transgene expression in plants
7456333 Transgenic non-human mammals as models for human pathologies of stem cell origin
7456298 Synthesis of acetonides from aryl silanes

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Companies working in the area of Phenotype from Bioportfolio's Biocorporate database :

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Clingenix Incorporated

Clingenix, Inc. was founded in 1998 by leading scientists from Harvard, Stanford, and private industry to provide pharmacogenomic as well as conventional research, development and application services...
www.clingenix.com/        View full profile
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Epigenomics AG

Epigenomics is a transatlantic biotechnology company with headquarters in Berlin, Germany and its wholly owned subsidiary in Seattle, Washington, USA, pioneering tomorrow´s personalized medicines. By...
www.epigenomics.de/        View full profile
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Epigenomics Incorporated

Epigenomics is a transatlantic biotechnology company with headquarters in Berlin, Germany and its wholly owned subsidiary in Seattle, Washington, USA, pioneering tomorrow´s personalized medicines. By...
www.epigenomics.com/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Phenotype scientists - we have details of around 20857 individuals working on Phenotype .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.

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