Phospholipase C

This article is about phosphoinositide phospholipase C . For other types of phospholipase C enzymes, see Phospholipase C .Phosphoinositide phospholipase C represents a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. In general, this enzyme is denoted as phospholipase C, although three other families of phospholipase C enzymes have been identified in bacteria and in trypanosomes. Different phospholipase Cs participate in phosphatidylinositol bisphosphate metabolism and lipid signaling pathways in a calcium-dependent manner. At present, the superfamily consists of six sub-families comprising a total of 13 separate isoforms that differ in their mode of activation, catalytic regulation, cellular localization, membrane binding avidity, and tissue distribution. All are capable of catalyzing the hydrolysis of PIP₂ into two important second messenger molecules, which go on to alter cell responses such as proliferation, differentiation, apoptosis, cytoskeleton remodeling, vesicular trafficking, ion channel conductance, endocrine function, and neurotransmission. (From the Wikpedia article Phospholipase C.)

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Recent Publications on Phospholipase C:
SERPINA3K prevents oxidative stress induced necrotic cell death by inhibiting calcium overload. BACKGROUND: SERPINA3K, an extracellular serine proteinase inhibitor...	31st December, 2008	Department of Cell Biology, Department of Medicine, The University of	PLoS ONE. 2008;3(12):e4077. Epub 2008 Dec 30. DOI Direct Link
Phosphoinositide-Phospholipase C {beta}1 Mono-Allelic Deletion Is Associated With Myelodysplastic Syndromes Evolution Into Acute Myeloid Leukemia. PURPOSE: To evaluate the association between the presence of...	31st December, 2008	Cellular Signalling Laboratory, Department of Human Anatomical Sciences;	J Clin Oncol. 2008 Dec 29. DOI Direct Link
Angiopoietin-2 Exocytosis Is Stimulated by Sphingosine-1-Phosphate in Human Blood and Lymphatic Endothelial Cells. OBJECTIVE: Although diverse functions of angiopoietin-2 (Ang2) have been...	30th December, 2008	National Research Laboratory of Vascular Biology and Department of	Arterioscler Thromb Vasc Biol. 2008 Dec 26. DOI Direct Link
Metabotropic glutamate 1 receptor: current concepts and perspectives. Almost 25 years after the first report that glutamate can activate...	30th December, 2008	Department of Pharmacology, Innsbruck Medical University, Peter-Mayr	Pharmacol Rev. 2008 Dec;60(4):536-81. DOI Direct Link
Co-existence of muscarinic and nicotinic receptors and their functional interaction in mouse Beta-TC6 cells. Mouse Beta-TC6 insulinoma cells possessing nicotinic receptor [Ohtani, M.,...	27th December, 2008	Chemical Biology, National Institutes of Diabetes and Digestive and Kidney	Eur J Pharmacol. 2008 Dec 16. DOI Direct Link
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BioNews Results for Phospholipase C:
[Leukemia and Bone Marrow Transplantation] Phosphoinositide-Phospholipase C {beta}1 Mono-Allelic Deletion Is A	Journal of Clinical Oncology:  Dec 30 2008 12:40AM Matching: phospholipase c

Phospholipase C Patents:
US Patent No.	Title
7439255	Muscarinic acetylcholine receptor antagonists
7449461	Benzathiazol-acetamides
7452538	Death domain containing receptor 4 antibodies and methods
7452682	Identification of 5HT2A receptor ligands by selective amplification of cells transfected with receptors
7452685	T1R1 receptor binding assays for identification of taste modulators
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