Pseudohermaphroditism

Pseudohermaphroditism or pseudo-hermaphroditism, is a name used to describe people born with secondary sex characteristics or a phenotype which is different than would be expected based upon the gonadal tissue .In some cases, the external sex organs look intermediate between the typical vagina or penis. In other cases, the external sex organs have an appearance that does not look intermediate, but rather has the appearance that would be expected to be seen with the "opposite" gonadal tissue. Because of this, pseudohermaphroditism is sometimes not identified until puberty.The term "male pseudohermaphrodite" is used when a testis is present, and the term "female pseudohermaphrodite" is used when an ovary is present. The term "true" hermaphrodite is reserved for the very rare cases where both ovarian and testicular tissue is present. It is possible for the condition to be undetected until adulthood.Associated conditions in males include 5-alpha-reductase deficiency, and associated conditions in females include Turner's syndrome and Klinefelter's syndrome. (From the Wikpedia article Pseudohermaphroditism.)

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Recent Publications on Pseudohermaphroditism:
Frasier syndrome, a potential cause of end-stage renal failure in childhood. The diagnosis of Frasier syndrome is based on the association of male...	19th November, 2009	Nephrology Dialysis Children Unit University Hospital, Avenue Moliere,	Pediatr Nephrol. 2009 Nov 17. DOI Direct Link
A splice site mutation combined with a novel missense mutation of LHCGR cause male pseudohermaphroditism. Leydig cell hypoplasia (LCH) is a rare form of male pseudohermaphroditism...	18th November, 2009	Department of Endocrinology, Research Center of Tissue Engineering,	Hum Mutat. 2009 Sep;30(9):E855-65. DOI Direct Link
Natural mutations of the anti-Mullerian hormone type II receptor found in persistent Mullerian duct syndrome affect ligand binding, signal transduction and cellular transport. The anti-Mullerian hormone type II (AMHRII) receptor is the primary...	29th October, 2009	INSERM U782, 32 rue des Carnets, Clamart F-92140, France.	Hum Mol Genet. 2009 Aug 15;18(16):3002-13. Epub 2009 May 20. DOI Direct Link
[WT1 mutation as a cause of progressive nephropathy in Frasier syndrome--case report] Frasier syndrome is an uncommon genetic disorder featuring progressive...	9th October, 2009	Uniwersytet Medyczny w Bialymstoku, Klinika Pediatrii i Nefrologii.	Pol Merkur Lekarski. 2009 Jun;26(156):642-4.
Surgical Treatment of Hermaphroditism: Experience With 25 Cases. This article is a summary of our experience with surgical treatment of 25...	7th October, 2009	From the Department of Plastic Surgery, Changhai Hospital, Second Military	Ann Plast Surg. 2009 Oct 2. DOI Direct Link
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Pseudohermaphroditism Patents:
US Patent No.	Title
6946134	Albumin fusion proteins
7189690	Albumin fusion proteins
7196076	Androgen receptor modulators and methods of use thereof
7196164	Secreted protein HHTLF25
7232667	Keratinocyte growth factor-2 polynucleotides
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