Raf Kinases

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Recent Publications on Raf Kinases:
Isoform-specific interaction of C-RAF with mitochondria. The proteins of the RAF family (A-RAF, B-RAF, and C-RAF) are...	19th July, 2008	Institut fur Medizinische Strahlenkunde und Zellforschung, University of	J Biol Chem. 2008 May 23;283(21):14857-66. Epub 2008 Mar 20. DOI Direct Link
Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation. The two-pore domain K(+) channel, TRESK (TWIK-related spinal cord K(+)...	17th July, 2008	Department of Physiology, Semmelweis University, H-1444 Budapest, Hungary.	J Biol Chem. 2008 Jun 6;283(23):15672-80. Epub 2008 Apr 8. DOI Direct Link
Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila. The proto-oncoprotein Raf is pivotal for mitogen-activated protein kinase...	11th July, 2008	Department of Biomedical Genetics, University of Rochester Medical Center,	PLoS Biol. 2008 May 20;6(5):e128. DOI Direct Link
[Use of sorafenib (Nexavar) in the treatment of hepatocellular carcinoma: PRODIGE AFEF recommendations] The proteins of the RAF family (A-RAF, B-RAF, and C-RAF) are...	11th July, 2008	Departement de medecine, institut Gustave-Roussy, 39, rue	Gastroenterol Clin Biol. 2008 Jan;32(1 Pt. 1):3-7. Epub 2008 Mar 4. DOI Direct Link
Metastatic melanoma: scientific rationale for sorafenib treatment and clinical results. In advanced metastatic melanoma (AJCC stage IV), the prognosis is still...	4th July, 2008	Department of Dermatology, University Hospital of Schleswig-Holstein,	Onkologie. 2008 Jul;31(7):398-403. Epub 2008 Jun 23. DOI Direct Link
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Raf Kinases Clinical Trials:
An Open-Label, Non-Comparative, Phase III Study of the Raf-Kinase Inhibitor BAY 43-9006 as a Subsequent to First-Line Therapy in Patients With Advanced Renal Cell Carcinoma	Cancer;   Renal Cell Cancer (RCC)

Raf Kinases Patents:
US Patent No.	Title
6506798	4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
6916846	Coumermycin analogs as chemical dimerizers of chimeric proteins
6960614	Oxygenated esters of 4-lodo phenylamino benzhydroxamic acids
6987119	Imidazol-2-carboxamide derivatives as raf kinase inhibitors
6998391	Method for treating diseases associated with abnormal kinase activity
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