Recent Publications on Ral Gtp-Binding Proteins: |  |
The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells.
RalA is a small GTPase that is thought to facilitate exocytosis through...
Direct Link | 19th August, 2008
| Diabetes and Obesity Program, Garvan Institute of Medical Research,
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Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells.
The small GTP-binding protein Ral has been implicated in regulated...
Direct Link | 18th July, 2008
| Department of Plasma Proteins, Sanquin Research and Landsteiner Laboratory
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Characterization of RalB-Sec5-TBK1 function in human oncogenesis.
The Ras-like GTPases, RalA and RalB, are key components of the oncogenic...
Direct Link | 20th June, 2008
| Department of Cell Biology, University of Texas Southwestern Medical
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Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway.
Non-hydrolyzable GTP analogues, such as guanosine 5'-(beta,...
Direct Link | 18th June, 2008
| Department of Cardiovascular Medicine and Frontier Technology Center,
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The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells.
Chemokine-controlled migration plays a critical role in B-cell...
Direct Link | 16th May, 2008
| Department of Pathology, Academic Medical Center, University of Amsterdam,
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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth.
Geranylgeranyltransferase I inhibitors (GGTIs) are presently undergoing...
Direct Link | 28th March, 2008
| Drug Discovery Program, The H. Lee Moffitt Cancer Center & Research
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Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.
Phospholipase D (PLD) is elevated in rodent fibroblasts expressing...
Direct Link | 18th March, 2008
| Department of Biological Sciences, Hunter College of The City University
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RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.
The small Ras-like GTPase Rap1 has been identified as a regulator of...
Direct Link | 8th March, 2008
| Department of Physiological Chemistry, Centre for Biomedical Genetics, UMC
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Ral GTPases and cancer: linchpin support of the tumorigenic platform.
A confluence of recent observations has indicted the Ras-family G-proteins...
Direct Link | 22nd February, 2008
| Department of Cell Biology, University of Texas Southwestern Medical
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Activation of the RalGEF/Ral pathway promotes prostate cancer metastasis to bone.
A hallmark of metastasis is organ specificity; however, little is known...
Direct Link | 6th December, 2007
| Cell and Cancer Biology Branch, Center for Cancer Research, National
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PP2A: unveiling a reluctant tumor suppressor.
Although evidence has suggested that the serine/threonine protein...
Direct Link | 6th December, 2007
| Department of Pharmacology, University of Texas Southwestern Medical
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Mass spectroscopic phosphoprotein mapping of Ral binding protein 1 (RalBP1/Rip1/RLIP76).
RalBP1, a multifunctional protein implicated in cancer cell proliferation,...
Direct Link | 24th October, 2007
| Department of Molecular Physiology and Biological Physics, University of
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Ral-GTPase interacts with the beta1 subunit of Na+/K+-ATPase and is activated upon inhibition of the Na+/K+ pump.
Na+/K+-ATPase functions as both an ion pump and a signal transducer....
Direct Link | 17th October, 2007
| Department of Oral Biology, University of Manitoba, 744 Bannatyne Avenue,
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Expression of ral GTPases, their effectors, and activators in human bladder cancer.
PURPOSE: The Ral family of small G proteins has been implicated in...
Direct Link | 7th September, 2007
| Department of Molecular Physiology, University of Virginia,
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The tumor suppressor PP2A Abeta regulates the RalA GTPase.
The serine-threonine protein phosphatase 2A (PP2A) is a heterotrimeric...
Direct Link | 19th July, 2007
| Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard
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