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Saposins

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Recent Publications on Saposins:
Proteomic analysis of enriched lysosomes at early phase of camptothecin-induced apoptosis in human U-937 cells. A lysosomal pathway, characterized by partial rupture or labilization of...	17th November, 2009	Centre de recherche, Centre hospitalier de l'Universite of Montreal	J Proteomics. 2009 Aug 20;72(6):960-73. Epub 2009 Apr 23. DOI Direct Link
Regional expression of prosaposin in the wild-type and saposin D-deficient mouse brain detected by an anti-mouse prosaposin-specific antibody. Prosaposin is a precursor of saposins A, B, C, and D. Saposins are...	13th November, 2009	Institute of Glycoscience, Tokai University, Kanagawa, Japan.	Proc Jpn Acad Ser B Phys Biol Sci. 2009;85(9):422-34.
The inactivation of the sortilin gene leads to a partial disruption of prosaposin trafficking to the lysosomes. Lysosomes are intracellular organelles which contain enzymes and activator...	7th November, 2009	Department of Anatomy and Cell Biology, McGill University, Montreal,	Exp Cell Res. 2009 Nov 1;315(18):3112-24. Epub 2009 Sep 2. DOI Direct Link
Lysosomal degradation of membrane lipids. The constitutive degradation of membrane components takes place in the...	20th October, 2009	LiMES - Life and Medical Sciences Institute, Membrane Biology and Lipid	FEBS Lett. 2009 Oct 16. DOI Direct Link
Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1. Metastatic tumors can prepare a distant site for colonization via the...	26th August, 2009	Vascular Biology Program, Department of Surgery, Children's Hospital	Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12115-20. Epub 2009 Jul 6. DOI Direct Link
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Saposins Patents:
US Patent No.	Title
7615224	Multiplex-bead complex for determination of lysosomal storage disorders
6559124	Use of prosaposin and peptides obtained therefrom for treatment of neural degeneration
6458357	Retro-inverso neurotrophic and analgesic peptides
6362003	Hematological reference control composition containing leukocyte analogs, methods of making, and uses thereof
6271196	Methods of alleviating neuropathic pain using prosaposin-derived peptides
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Saposins

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Recent Publications on Saposins:

Saposins Patents: