Saposins

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Recent Publications on Saposins:
Structures of the human ceramide activator protein saposin D. Saposin D is a sphingolipid activator protein required for the lysosomal...	1st July, 2008	Department of Medical Biophysics, University of Toronto, Toronto, Ontario,	Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):589-94. Epub 2008 DOI Direct Link
Neurological deficits and glycosphingolipid accumulation in Saposin B deficient mice. Saposin B derives from the multi-functional precursor, prosaposin, and...	16th May, 2008	The Division of Human Genetics, University of Cincinnati College of	Hum Mol Genet. 2008 May 14;. DOI Direct Link
Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions. Human saposins are essential proteins required for degradation of...	9th May, 2008	Institut fur Chemie und Biochemie, Kristallographie, Freie Universitat	Structure. 2008 May;16(5):809-17. DOI Direct Link
An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions - relevance for Gaucher disease. Gaucher disease, the most prevalent lysosomal storage disorder, is...	19th April, 2008	Departament de Genetica, Facultat de Biologia, Universitat de Barcelona,	Proteins. 2008 Feb 15;70(3):882-91. DOI Direct Link
Expression patterns in alternative splicing forms of prosaposin mRNA in the rat facial nerve nucleus after facial nerve transection. Prosaposin acts as a neurotrophic factor, in addition to its role as the...	12th April, 2008	Division of Anatomy and Embryology, Department of Integrated Basic Medical	Neurosci Res. 2008 Jan;60(1):82-94. Epub 2007 Oct 2. DOI Direct Link
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Saposins Patents:
US Patent No.	Title
7378231	Diagnosis of lysosomal storage disorders using saposins and other markers
6271196	Methods of alleviating neuropathic pain using prosaposin-derived peptides
6268347	Prosaposin-derived peptides
6103483	Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility
6100378	Enhancement of the pro-fertility action of a molecule involved in a sperm-egg binding
→View more patents.

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