Recent Publications on Saposins: |  |
Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice.
ABSTRACT: BACKGROUND: Prosaposin encodes, in tandem, four small acidic...
Direct Link | 5th August, 2008
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Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice.
Saposin B derives from the multi-functional precursor, prosaposin, and...
Direct Link | 5th August, 2008
| Division of Human Genetics, Cincinnati Children's Hospital Medical Center,
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The secretion and maturation of prosaposin and procathepsin D are blocked in embryonic neural progenitor cells.
The notion that prosaposin (Prosap) is likely involved in brain...
Direct Link | 2nd August, 2008
| Department of Hematology, Oncology and Molecular Medicine, Istituto
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Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions.
Human saposins are essential proteins required for degradation of...
Direct Link | 26th July, 2008
| Institut fur Chemie und Biochemie, Kristallographie, Freie Universitat
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D-SAP: a new, noncytotoxic, and fully protease resistant cell-penetrating peptide.
Protease resistant cell-penetrating peptides (CPPs) are promising carriers...
Direct Link | 24th July, 2008
| Institut de Recerca Biomedica, Parc Cientific de Barcelona, Josep Samitier
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Structures of the human ceramide activator protein saposin D.
Saposin D is a sphingolipid activator protein required for the lysosomal...
Direct Link | 1st July, 2008
| Department of Medical Biophysics, University of Toronto, Toronto, Ontario,
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An evolutionary and structure-based docking model for glucocerebrosidase-saposin C and glucocerebrosidase-substrate interactions - relevance for Gaucher disease.
Gaucher disease, the most prevalent lysosomal storage disorder, is...
Direct Link | 19th April, 2008
| Departament de Genetica, Facultat de Biologia, Universitat de Barcelona,
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Expression patterns in alternative splicing forms of prosaposin mRNA in the rat facial nerve nucleus after facial nerve transection.
Prosaposin acts as a neurotrophic factor, in addition to its role as the...
Direct Link | 12th April, 2008
| Division of Anatomy and Embryology, Department of Integrated Basic Medical
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Conformational dynamics of a lipid-interacting protein: MD simulations of saposin B.
Saposin B is a water soluble alpha-helical protein which can bind to...
Direct Link | 6th March, 2008
| Department of Biochemistry, University of Oxford, UK.
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Distribution of prosaposin in the rat nervous system.
Prosaposin is the precursor of four sphingolipid activator proteins...
Direct Link | 26th February, 2008
| Department of Neuropsychiatry, Ehime University Graduate School of
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| [Organization of Gaucher disease management in France]
| 19th February, 2008
| Service de Medecine Interne - Assistance Publique-Hopitaux de Paris,
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Non-neuronopathic Gaucher disease due to saposin C deficiency.
Gaucher disease is generally caused by a deficiency of the lysosomal...
Direct Link | 23rd January, 2008
| Department of Metabolic Diseases, Endocrinology, and Diabetology, The
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The function of sphingolipids in the nervous system: lessons learnt from mouse models of specific sphingolipid activator protein deficiencies.
We have generated specific saposin A and D deficient mouse mutants by the...
Direct Link | 4th January, 2008
| Institute of Glycotechnology, Future Science and Technology Joint Research
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Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C.
Acid beta-glucosidase (GCase) is a soluble lysosomal enzyme responsible...
Direct Link | 28th December, 2007
| Division of Cancer Genomics and Proteomics, Ontario Cancer Institute, 101
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| [Reciprocal epithelio-stromal interactions in normal and neoplastic prostate]
| 25th October, 2007
| Universitatea de Medicina si Farmacie Gr. T. Popa Iasi, Facultatea de
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