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SarcolemmaThe sarcolemma is the cell membrane of a muscle cell. The membrane is designed to receive and conduct stimuli. Alterations in the sarcolemmal membrane stability and repair system can lead to muscular dystrophy. The mechanism of muscular dystrophy is lack of functional dystrophin. This means that the sarcolemma is not attached to the cytoskeleton. Therefore during muscle contraction, the sarcolemma is not synchronized with the interior of the cell. The looseness of the sarcolemma permits membrane calcium channels to open. The rise in internal calcium ions causes activation of the proteolytic enzyme calpain, which digests proteins including contractile proteins, rendering the muscle much weaker.The sarcolemma invaginates into the cytoplasm of the muscle cell, forming membranous tubules called transverse tubules . Sarcoplasmic reticulum is the enlargement of smooth endoplasmic reticulum found in muscle cells on either side of the transverse tubules. The triad of transverse tubules surrounded by two smooth ER cisternae transmit altered membrane permeability down the tubules. The nuclei lie just adjacent to the sarcolemma, at the periphery of the fiber.This membrane is extensible and encloses the contractile substance of a muscle fiber. (From the Wikpedia article Sarcolemma.) Download PDFImage ResultsLoading...
BioPortfolio Ltd. offers e-mail and postal lists for Sarcolemma scientists - we have details of around 690 individuals working on Sarcolemma . This page has been viewed 99 times Browse BioPortfolio's InDepth service - alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z or by Most Publications, recently searched for, or most viewed. Search for Sarcolemma across BioPortfolio, or bestselling Sarcolemma books or recently published Sarcolemma books . Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. | ||||||||||||||||||||||||||||||
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