Smallpox

Smallpox is an acute infectious disease unique to humans, caused by either of two virus variants named Variola major and Variola minor. Also known by the Latin names Variola or Variola vera; a derivative of the Latin varius, meaning spotted, or varus, meaning "pimple". The term "smallpox" was first used in Europe in the 15th century to distinguish variola from the great pox . Smallpox localizes in small blood vessels of the skin and in the mouth and throat. In the skin, this results in the characteristic maculopapular rash, which evolves into raised vesicles, then into fluid-filled pustules. V. major produces a more serious disease and has an overall mortality rate of 30–35%. V. minor causes a milder form of disease which kills ~1% of its victims. Blindness resulting from corneal ulceration and scarring, and limb deformities due to arthritis and osteomyelitis are less common complications, seen in about 2-5% of cases.Smallpox is believed to have emerged in human populations about 10,000 BC. During the 20th century, it is estimated that smallpox was responsible for 300–500 million deaths. As recently as 1967, the World Health Organization estimated that 15 million people contracted the disease and that two million died in that year. After successful vaccination campaigns throughout the 19th and 20th centuries, the WHO certified the eradication of smallpox in 1979. (From the Wikpedia article Smallpox.)

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Recent Publications on Smallpox:
A mouse-based assay for the pre-clinical neurovirulence assessment of vaccinia virus-based smallpox vaccines. Post-vaccinal encephalitis, although relatively uncommon, is a known...	10th November, 2009	FDA, Division of Viral Products, Building 29A, Room 2C-20, Lincoln Drive,	Biologicals. 2009 Nov 5. DOI Direct Link
Production of pharmaceutical-grade plasmids at high concentration and high supercoiled percentage. The increased use of plasmid-based vaccines to replace their more...	10th November, 2009	VGX Pharmaceuticals, Inc., The Woodlands, TX 77381, United States.	Vaccine. 2009 Nov 4. DOI Direct Link
Capturing of cell culture-derived modified Vaccinia Ankara virus by ion exchange and pseudo-affinity membrane adsorbers. Smallpox is an acute, highly infectious viral disease unique to humans,...	6th November, 2009	Bioprocess Engineering, Max Planck Institute for Dynamics of Complex	Biotechnol Bioeng. 2009 Nov 4. DOI Direct Link
In vitro Prevention of Vaccinia and Herpesvirus Infection Spread in Explanted Human Corneas by N-Chlorotaurine. Objective: Weak oxidants produced by activated human leukocytes are proven...	6th November, 2009	Department of Hygiene, Microbiology and Social Medicine, Innsbruck Medical	Ophthalmic Res. 2009 Nov 2;43(3):145-152. DOI Direct Link
Recombinant A27 protein synergizes with modified vaccinia Ankara in conferring protection against a lethal vaccinia virus challenge. Highly attenuated modified vaccinia virus Ankara (MVA) is being considered...	6th November, 2009	Division of Viral Products, Center for Biologics Evaluation and Research,	Vaccine. 2009 Oct 31. DOI Direct Link
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Press Releases About Smallpox:
The Government of Canada Procures IMVAMUNE(R) Smallpox Vaccine for the Country's Biological Preparedness	1st December, 2008		KVISTGARD, Denmark, December 1 /PRNewswire/ -- Following a Request for Proposal issued in 2007 with the intent to procure an MVA-based, third generation smallpox vaccine, Public Works and Government
Affymetrix Announces Completion of Smallpox Array Set Developed with CDC	1st January, 1970	Affymetrics	Affymetrix Announces Completion of Smallpox Array Set Developed with CDC - Seven-Array Set Will Enable Rapid Resequencing of the Entire Smallpox Genome - SANTA CLARA, Calif., Feb. 19 --
The Licensing Review contains news, analysis and opinions on the	1st January, 1970	Datamonitor	Datamonitor October edition of The Licensing Review contains news, analysis and opinions on the healthcare licensing industry. Scope
The Infectious Diseases Review brings you the latest news, expert	1st January, 1970	Datamonitor	Datamonitor's October edition of the Infectious Diseases Review brings you the latest news, expert analysis and research in the infectious

BioNews Results for Smallpox:
Fearing a flu vaccine, and wanting more of it	Helena Independent:  Nov 12 2009 10:31PM Matching: smallpox
Chimerix to Present at Two Upcoming Investor Conferences	Freshnews.com:  Nov 12 2009 2:20PM Matching: smallpox
Chimerix to Present at Two Upcoming Investor Conferences	Pharma Live:  Nov 12 2009 2:15PM Matching: smallpox
BUY OR SELL-U.S. order key for vaccine maker Bavarian Nordic	Forbes.com:  Nov 12 2009 2:42PM Matching: smallpox
BUY OR SELL-U.S. order key for vaccine maker Bavarian Nordic	FinanzNachrichten.de:  Nov 12 2009 2:38PM Matching: smallpox
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Smallpox Clinical Trials:
Safety, Tolerability, and Immune Response of ACAM3000 Modified Vaccinia Ankara (MVA) Smallpox Vaccine in Adults

Smallpox Patents:
US Patent No.	Title
7569188	Surface plasmon amplification by stimulated emission of radiation (SPASER)
7576319	Systems for differential ion mobility analysis
7576854	Arrays of nano structures for surface-enhanced raman scattering
7578969	Decontamination system for mail and other articles
7579004	Naturally processed measles virus peptides eluted from class II HLA molecules
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Companies working in the area of Smallpox from Bioportfolio's Biocorporate database :
Company Name
Acambis plc Acambis is a biopharmaceutical company discovering, developing and manufacturing vaccines to prevent and treat infectious diseases. Employing some 160 people, it is based in Cambridge, UK, and... www.acambis.com/        View full profile
Cangene Corporation Cangene is a world leader in the development , manufacture, and commercialization of specialty hyperimmune plasma and biotechnology products. Cangene has built two decades of success with the life... www.cangene.com/        View full profile
Chimerix, Inc Chimerix Inc. is a privately held biotechnology company creating and developing orally available medicines from bioactive molecules. Application of Chimerix's proprietary technology enhances oral... www.chimerix-inc.com/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Smallpox scientists - we have details of around 767 individuals working on Smallpox .