Sphingolipidoses

Sphingolipidoses are a class of disorders relating to Sphingolipid metabolism.Examples include:* Fabry's disease* Gangliosidosis** GM1 gangliosidoses** GM2 gangliosidoses*** Tay-Sachs disease*** Sandhoff disease* Gaucher's disease* Krabbe disease* Metachromatic leukodystrophy* Niemann-Pick disease (From the Wikpedia article Sphingolipidoses.)

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Recent Publications on Sphingolipidoses:
Musculoskeletal manifestations of lysosomal storage disorders. Lysosomal storage disorders (LSDs), a heterogeneous group of inborn...	18th November, 2009	Department of Paediatric Immunology/Haematology and SCT, University	Ann Rheum Dis. 2009 Nov;68(11):1659-65. DOI Direct Link
Glycosphingolipids--nature, function, and pharmacological modulation. The discovery of the glycosphingolipids is generally attributed to Johan...	29th October, 2009	Leiden Institute of Chemistry, Gorlaeus Laboratories, Leiden University,	Angew Chem Int Ed Engl. 2009;48(47):8848-69. DOI Direct Link
Molecular facets of sphingolipids: mediators of diseases. Sphingolipids constitute a biologically active lipid class that is...	22nd October, 2009	Department of Chemical Engineering, Bogazici University, Bebek, Istanbul,	Biotechnol J. 2009 Jul;4(7):1028-41. DOI Direct Link
Cholesterol regulation of rab-mediated sphingolipid endocytosis. Despite a tight regulation of its intracellular content, cholesterol is...	2nd October, 2009	VCAD System Research Program, Bio-research Infrastructure Construction	Glycoconj J. 2009 Aug;26(6):705-10. Epub 2008 Oct 8. DOI Direct Link
Normal phase liquid chromatography coupled to quadrupole time of flight atmospheric pressure chemical ionization mass spectrometry for separation, detection and mass spectrometric profiling of neutral sphingolipids and cholesterol. Many lipidomic approaches focus on investigating aspects of sphingolipid...	4th August, 2009	LiMES - Life and Medical Sciences Institute, Membrane Biology and Lipid	J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):2976-82. DOI Direct Link
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Sphingolipidoses Patents:
US Patent No.	Title
4639437	Kit or device and method for administering gangliosides and derivatives thereof by inhalation and pharmaceutical compositions suitable therefor
5710028	Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
5714478	Sphingosylphosphorylcholine as a wound-healing agent
5773278	Acid sphingomyelinase gene
5792858	Lysosphingolipid derivatives
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BioPortfolio Ltd. offers e-mail and postal lists for Sphingolipidoses scientists - we have details of around 38 individuals working on Sphingolipidoses .