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Tacrolimus Binding Protein 1a

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Recent Publications on Tacrolimus Binding Protein 1a:

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A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis.
The mammalian target of rapamycin (mTOR) inhibitor CCI-779 (temsirolimus)...		11th June, 2008
Discovery Oncology, Wyeth Research, Pearl River, NY 10965, USA. Cancer Res. 2008 Apr 15;68(8):2934-43.
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Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release.
A number of RyR2 (cardiac ryanodine receptor) mutations linked to...		22nd May, 2008
Department of Physiology and Biophysics, University of Calgary, Calgary, Biochem J. 2008 May 15;412(1):171-8.
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RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle.
Ryanodine receptor subtype 1 (RyR1) has been primarily characterized in...		6th May, 2008
CNRS UMR 5017, Laboratoire de Signalisation et Interactions Cellulaires, J Cell Sci. 2007 Nov 1;120(Pt 21):3784-91. Epub 2007 Oct 9.
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Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR.
The mammalian target of rapamycin (mTOR) is a large, multidomain protein...		23rd April, 2008
Department of Biochemistry, University of Leicester, Leicester, UK. Oncogene. 2008 Jan 24;27(5):585-95. Epub 2007 Aug 6.
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Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors.
Peptidyl-prolyl cis-trans isomerases are a group of cytosolic enzymes...		4th April, 2008
Infectious and Inflammatory Disease Center, Burnham Institute for Medical J Med Chem. 2007 Dec 27;50(26):6607-17. Epub 2007 Nov 27.
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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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