Recent Publications on Tacrolimus Binding Protein 1a: |  |
FK506-binding protein (FKBP12) regulates ryanodine receptor-evoked Ca2+ release in colonic but not aortic smooth muscle.
In smooth muscle, the ryanodine receptor (RyR) mediates Ca(2+) release...
Direct Link | 6th September, 2008
| Division of Physiology and Pharmacology, Strathclyde Institute of Pharmacy
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FK506 binding protein 12 differentially accelerates fibril formation of wild type alpha-synuclein and its clinical mutants A30P or A53T.
Aggregation of alpha-synuclein (alpha-SYN) plays a key role in Parkinson's...
Direct Link | 20th August, 2008
| Laboratory of Biomolecular Dynamics, K. U. Leuven, Flanders, Belgium.
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Conditional transgenesis using Dimerizable Cre (DiCre).
Cre recombinase is extensively used to engineer the genome of experimental...
Direct Link | 9th August, 2008
| ICNE-UMR 6544 Centre National de Recherche Scientifique (CNRS), Universite
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A new pharmacologic action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis.
The mammalian target of rapamycin (mTOR) inhibitor CCI-779 (temsirolimus)...
Direct Link | 11th June, 2008
| Discovery Oncology, Wyeth Research, Pearl River, NY 10965, USA.
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Endoplasmic reticulum Ca2+ measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+ release.
A number of RyR2 (cardiac ryanodine receptor) mutations linked to...
Direct Link | 22nd May, 2008
| Department of Physiology and Biophysics, University of Calgary, Calgary,
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RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle.
Ryanodine receptor subtype 1 (RyR1) has been primarily characterized in...
Direct Link | 6th May, 2008
| CNRS UMR 5017, Laboratoire de Signalisation et Interactions Cellulaires,
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Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors.
Peptidyl-prolyl cis-trans isomerases are a group of cytosolic enzymes...
Direct Link | 4th April, 2008
| Infectious and Inflammatory Disease Center, Burnham Institute for Medical
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Neointimal expression of rapamycin receptor FK506-binding protein FKBP12: postinjury animal and human in-stent restenosis tissue characteristics.
Despite excellent clinical results for sirolimus (rapamycin)-eluting...
Direct Link | 18th March, 2008
| Department of Internal Medicine II - Cardiology, University of Bonn, Bonn,
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Requirements for peptidyl-prolyl isomerization activity: a comprehensive mutational analysis of the substrate-binding cavity of FK506-binding protein 12.
Peptidyl-prolyl isomerase (PPIase) activity is exhibited by many proteins...
Direct Link | 12th February, 2008
| Laboratory of Structural Biology, School of Biomedical Science, Tokyo
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| [A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase]
| 25th January, 2008
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Distinctive expression and functional regulation of the maize (Zea mays L.) TOR kinase ortholog.
TOR (Target of rapamycin) kinase is a central component of a signal...
Direct Link | 25th January, 2008
| Departamento de Bioquimica, Facultad de Quimica, UNAM, Ciudad
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Overexpression of FK-506 binding protein 12.0 modulates excitation contraction coupling in adult rabbit ventricular cardiomyocytes.
The effect of the 12-kDa isoform of FK-506-binding protein (FKBP)12.0 on...
Direct Link | 14th December, 2007
| Department of Cardiology and Pneumology, Georg-August-University
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Accurate and efficient corrections for missing dispersion interactions in molecular simulations.
In simulations, molecular dispersion interactions are frequently neglected...
Direct Link | 7th December, 2007
| Department of Chemistry, Columbia University, New York, New York 10027,
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Cell signaling. mTOR, unleashed.
Peptidyl-prolyl isomerase (PPIase) activity is exhibited by many proteins...
Direct Link | 6th December, 2007
| Department of Biochemistry and Molecular Biology, University of British
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Increased striatal mRNA and protein levels of the immunophilin FKBP-12 in experimental Parkinson's disease and identification of FKBP-12-binding proteins.
FKBP-12, a 12 kDa FK506-binding protein (neuroimmunophilin), acts as a...
Direct Link | 6th December, 2007
| Laboratory for Biological and Medical Mass Spectrometry, Uppsala
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