Telomerase

Telomerase is an enzyme that adds specific DNA sequence repeats to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. The telomeres contain condensed DNA material, giving stability to the chromosomes. The enzyme is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. Telomerase was discovered by Carol W. Greider and Elizabeth Blackburn in 1984 in the ciliate Tetrahymena. (From the Wikpedia article Telomerase.)

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Recent Publications on Telomerase:
The teleost Oryzias latipes shows telomere shortening with age despite considerable telomerase activity throughout life. Previous studies of telomeres and telomerase have focused mostly on...	4th July, 2008	Laboratory of Comparative Cellular Biology, Nippon Veterinary and Life	Mech Ageing Dev. 2008 May 27;. DOI Direct Link
TDAG51 is an ERK signaling target that opposes ERK-mediated HME16C mammary epithelial cell transformation. ABSTRACT: INTRODUCTION: Signaling downstream of Ras is mediated by three...	4th July, 2008		BMC Cancer. 2008 Jul 2;8(1):189. DOI Direct Link
Defining Stem and Progenitor Cells within Adipose Tissue. Adipose tissue-derived stem cells (ADSC) are routinely isolated from the...	4th July, 2008	UCSF, Urology, San Francisco, California, United States;	Stem Cells Dev. 2008 Jul 2;. DOI Direct Link
A New Approach to Amplified Telomerase Detection with Polyvalent Oligonucleotide Nanoparticle Conjugates. Adipose tissue-derived stem cells (ADSC) are routinely isolated from the...	4th July, 2008		J Am Chem Soc. 2008 Jul 3;. DOI Direct Link
eNOS-ERalpha complex goes to telomerase. Adipose tissue-derived stem cells (ADSC) are routinely isolated from the...	4th July, 2008		Circ Res. 2008 Jul 3;103(1):10-2. DOI Direct Link
→View more research publications.

BioNews Results for Telomerase:
Mutations Affecting Telomerase Implicated in Premature Aging Syndrome	Abstracts in Hematology and Oncology:  Jun 3 2008 4:57PM Matching: telomerase
Pharmexa Stops One of Two Phase III Trials	Pharma Live:  May 13 2008 11:47AM Matching: telomerase

Telomerase Clinical Trials:
GV 1001 Immunotherapy in Patients With Non-Small Cell Lung Cancer (NSCLC)	Carcinoma, Non-Small-Cell Lung
Safety and Dose Study of GRN163L Administered Weekly to Treat Patients With Refractory or Relapsed Multiple Myeloma	Multiple Myeloma
Folfox-B Study for Patients With Colorectal Liver Metastases	Colorectal Liver Metastases
Dendritic Cell Based Therapy of Malignant Melanoma	Advanced Melanoma
Dendritic Cell Based Therapy of Renal Cell Carcinoma	Advanced Renal Cell Carcinoma
→View more trials.

Telomerase Patents:
US Patent No.	Title
7371824	PRO6093 polypeptides
7378487	PRO19675 polypeptides
7378491	Secreted and transmembrane polypeptides and nucleic acids encoding the same
7378492	CD40-related receptor that binds CD40L
7378501	Secreted and transmembrane polypeptides and nucleic acids encoding the same
→View more patents.

Companies working in the area of Telomerase from Bioportfolio's Biocorporate database :
Company Name
Geron Geron Corporation is a biopharmaceutical company focused on discovering and developing therapeutic and diagnostic products to treat cancer and other age-related degenerative diseases. The Company is... www.geron.com/        View full profile
Gemvax AS GemVax is a subsidiary of the Danish biotech company Pharmexa. The company is based on cancer vaccine technology developed over the last fourteen years at the Norwegian Radium Hospital in Oslo. GemVax... www.gemvax.com/        View full profile
Pharmexa Pharmexa is a leading biotech company in the field of active immunotherapy and vaccines for the treatment of cancer, serious chronic and infectious diseases. The company has been listed on the... www.me.dk/        View full profile
→View more Telomerase related companies.

BioPortfolio Ltd. offers e-mail and postal lists for Telomerase scientists - we have details of around 750 individuals working on Telomerase .

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