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Telomerase

Telomerase is an enzyme that adds specific DNA sequence repeats to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. The telomeres contain condensed DNA material, giving stability to the chromosomes. The enzyme is a reverse transcriptase that carries its own RNA molecule, which is used as a template when it elongates telomeres, which are shortened after each replication cycle. Telomerase was discovered by Carol W. Greider and Elizabeth Blackburn in 1984 in the ciliate Tetrahymena. (From the Wikpedia article Telomerase.)

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Recent Publications on Telomerase:

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Glucagon Like Peptide-1-Directed Human Embryonic Stem Cells Differentiation Into Insulin-Producing Cells Via Hedgehog, cAMP, and PI3K Pathways.
OBJECTIVES:: That glucagonlike peptide-1 (GLP-1) induces differentiation...
20th November, 2009
From the *UCLA Center of Excellence in Pancreatic Disease, David Geffen Pancreas. 2009 Nov 16.
DOI Direct Link
Effects of milk replacer formulation on measures of mammary growth and composition in Holstein heifers.
Overfeeding prepubertal heifers may impair mammary parenchymal growth and...
20th November, 2009
Department of Dairy Science, Virginia Polytechnic Institute and State J Dairy Sci. 2009 Dec;92(12):5937-5950.
DOI Direct Link
Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis.
Proliferation in the subependymal zone (SEZ) and neurogenesis in the...
20th November, 2009
Departamento de Biologia Celular and Centro de Investigacion Biomedica en J Neurosci. 2009 Nov 18;29(46):14394-14407.
DOI Direct Link
[Construction of an expression vector carrying short hairpin RNA targeting hTERT gene and its effects on breast cancer cell telomerase activity and proliferation in vivo.]
OBJECTIVE: To construct a RNA interference expression vector targeting...
20th November, 2009
Department of Plastic and Reconstructive Surgery, First Affiliated Nan Fang Yi Ke Da Xue Xue Bao. 2009 Nov 20;29(11):2187-2190.
In this issue.
SHIGELLOSIS, DYSENTERY - BY WHATEVER NAME - DON'T KISS THE CHIMPS: pp....
19th November, 2009
Proteomics. 2009 Nov 17;9(22).
DOI Direct Link

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Press Releases About Telomerase:

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UCSF Scientist Receives Nobel Prize in Physiology or Medicine 5th October, 2009 University of California, San Francisco
SAN FRANCISCO, Oct. 5 /PRNewswire-USNewswire/ -- Molecular biologist Elizabeth H. Blackburn, PhD, 60, of the University of California, San Francisco, today was named to receive the 2009 Nobel Prize in
Lytix Biopharma and KAEL-GemVax Announce Joint Clinical Trial to Combine LTX-315 and GV1001 Cancer Immunotherapy 19th June, 2009 Lytix Biopharma AS
TROMS0, Norway and SEOUL, Korea, June 19 /PRNewswire/ -- The Norwegian biopharmaceutical company Lytix Biopharma and Korean company KAEL-GemVax today announced the signing of a collaborative
RevGenetics Releases Its New Science-Based Telomere Health Supplement Formulation for DNA and Chromosome Health 18th May, 2009 RevGenetics
Astral Fruit, a new health supplements product, helps slow and repair some of the natural telomere DNA shortening that happens as we age MIAMI, May 18 /PRNewswire/ -- RevGenetics announces the update

BioNews Results for Telomerase:

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Geron Presents Interim Clinical Data on Its Telomerase Inhibitor Drug at AACR-NCI-EORTC
Individual.com:  Nov 20 2009 8:41AM Matching: telomerase
Geron Corporation (GERN) Presents Interim Clinical Data on Its Telomerase Inhibitor Drug at AACR-NCI-EORTC
BioSpace:  Nov 19 2009 7:18PM Matching: telomerase
Geron Presents Interim Clinical Data on Its Telomerase Inhibitor Drug at AACR-NCI-EORTC
SmartBrief:  Nov 19 2009 6:31PM Matching: telomerase
Geron Presents Interim Clinical Data on Its Telomerase Inhibitor Drug at AACR-NCI-EORTC
Genetic Engineering News:  Nov 19 2009 1:59PM Matching: telomerase
Geron Presents Interim Clinical Data on Its Telomerase Inhibitor Drug at AACR-NCI-EORTC
San Jose Mercury News:  Nov 19 2009 1:51PM Matching: telomerase
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Telomerase Patents:

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US Patent No.Title
7582635 Therapeutic agents useful for treating pain
7592367 Compounds from Garcinia hanburyi, their use in treating cancer and method of separating epimers thereof
7592422 Modified plasminogen activator inhibitor type-1 and methods based thereon
7595378 Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
7597890 Methods and compositions for diagnosing lung cancer

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Companies working in the area of Telomerase from Bioportfolio's Biocorporate database :

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Company Name

Geron

Geron Corporation is a biopharmaceutical company focused on discovering and developing therapeutic and diagnostic products to treat cancer and other age-related degenerative diseases. The Company is...
www.geron.com/        View full profile
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Ambry Genetics

Ambry Genetics provides answers to clinicians, patients, and researchers with comprehensive, reliable, and state-of-the-art DNA diagnostic testing. The Company is well known for its Cystic Fibrosis...
www.ambrygen.com/        View full profile
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Pharmexa

Pharmexa is a leading biotech company in the field of active immunotherapy and vaccines for the treatment of cancer, serious chronic and infectious diseases. The company has been listed on the...
www.me.dk/        View full profile
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BioPortfolio Ltd. offers e-mail and postal lists for Telomerase scientists - we have details of around 750 individuals working on Telomerase .


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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

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