Telomere

A telomere is a region of highly repetitive DNA at the end of a linear chromosome that functions as a disposable buffer. Every time linear chromosomes are replicated during late S phase, the DNA polymerase complex is incapable of replicating all the way to the end of the chromosome; if it were not for telomeres, this would quickly result in the loss of vital genetic information, which is needed to sustain a cell's activities. Every time a cell with linear chromosomes divides, it will lose a small piece of one of its strands of DNA. This process has been referred to by James Watson and Alexei Olovnikov as the "end replication problem" . It is believed that telomeres have a function in the aging process. (From the Wikpedia article Telomere.)

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Recent Publications on Telomere:
Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. Exo1 is a nuclease involved in mismatch repair, DSB repair, stalled...	30th August, 2008	Institute for Ageing and Health, Henry Wellcome Laboratory for	EMBO J. 2008 Aug 28. DOI Direct Link
Aminoacyl-Anthraquinone Conjugates as Telomerase Inhibitors: Synthesis, Biophysical and Biological Evaluation. The telomerase-telomere complex is a prospective anticancer target. To...	30th August, 2008	Department of Pharmaceutical Sciences, University of Padova, Via Marzolo	J Med Chem. 2008 Aug 28. DOI Direct Link
Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Idiopathic interstitial pneumonias (IIPs) have a progressive and often...	30th August, 2008	Departments of Oncology.	Proc Natl Acad Sci U S A. 2008 Aug 28. DOI Direct Link
Telomerase activity of HIV-1-specific CD8+ T cells: Constitutive upregulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Exhaustion of virus-specific T cells may play an important role in the...	30th August, 2008	Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA,	Blood. 2008 Aug 26. DOI Direct Link
Telomere structural dynamics in genome integrity control and carcinogenesis. Exhaustion of virus-specific T cells may play an important role in the...	30th August, 2008	Department of Cancer Biology, Dana Farber Cancer Institute, Boston,	Adv Exp Med Biol. 2005;570:311-41.
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BioNews Results for Telomere:
Keeping Cells Youthful: How Telomere-building Proteins Get Drawn Into the Fold	Innovations Report:  Aug 26 2008 2:08AM Matching: telomere
Keeping Cells Youthful: How Telomere-building Proteins Get Drawn Into The Fold	Science Daily:  Aug 25 2008 8:59PM Matching: telomere
Keeping Cells Youthful: How Telomere-building Proteins Get Drawn Into the Fold	Newswise:  Aug 24 2008 6:32PM Matching: telomere
Ouroboros On Biomarkers and Telomere Length	Longevity Meme:  Aug 22 2008 7:42PM Matching: telomere
Endometriosis enzyme	National Library for Health NHS:  Aug 6 2008 4:07PM Matching: telomere
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Telomere Clinical Trials:
Telomere Repair Gene Mutation in Inflammatory Bowel Disease	Inflammatory Bowel Disease;   IBD

Telomere Patents:
US Patent No.	Title
7335761	Avian gene expression controlling regions
7358040	MRE 11: modulation of cellular proliferation
7358330	Immunoregulatory compositions
7361475	Compositions and methods relating to colon specific genes and proteins
7361491	DNA molecules encoding human NHL, a DNA helicase
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Companies working in the area of Telomere from Bioportfolio's Biocorporate database :
Company Name
Geron Geron Corporation is a biopharmaceutical company focused on discovering and developing therapeutic and diagnostic products to treat cancer and other age-related degenerative diseases. The Company is... www.geron.com/        View full profile

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