Recent Publications on Ubiquitin-Protein Ligase Complexes: |  |
Spindle checkpoint activation at meiosis I advances anaphase II onset via meiosis-specific APC/C regulation.
During mitosis, the spindle assembly checkpoint (SAC) inhibits the...
Direct Link | 30th August, 2008
| Department of Chemistry, Shizuoka University, Suruga-ku, Shizuoka
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The anaphase-promoting complex/cyclosome (APC/C) is required for rereplication control in endoreplication cycles.
Endoreplicating cells undergo multiple rounds of DNA replication leading...
Direct Link | 16th August, 2008
| University of Cologne, Institute for Genetics, 50674 Koln, Germany.
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Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.
The ubiquitin ligase activity of the anaphase-promoting complex...
Direct Link | 13th August, 2008
| Yale University School of Medicine, Department of Molecular Biophysics and
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Two different mitotic checkpoint inhibitors of the anaphase-promoting complex/cyclosome antagonize the action of the activator Cdc20.
The mitotic checkpoint system ensures the fidelity of chromosome...
Direct Link | 9th August, 2008
| Unit of Biochemistry, Rappaport Faculty of Medicine, Technion-Israel
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The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
In response to DNA damage in G2, mammalian cells must avoid entry into...
Direct Link | 7th August, 2008
| Department of Pathology, NYU Cancer Institute, New York University School
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Cdc14B and APC/C tackle DNA damage.
Mitotic exit in budding yeast is regulated by the proteins Cdc14,...
Direct Link | 7th August, 2008
| Department of Experimental Oncology, European Institute of Oncology,
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Cdh1: a master G0/G1 regulator.
APC/C(Cdh1) controls the G0 and G1 phases of the cell cycle. Using a...
Direct Link | 5th August, 2008
| Department of Pathology, NYU Cancer Institute, New York University School
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Genomic stability and tumour suppression by the APC/C cofactor Cdh1.
The anaphase promoting complex or cyclosome (APC/C) is a ubiquitin protein...
Direct Link | 5th August, 2008
| Cell Division and Cancer Group, Centro Nacional de Investigaciones
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Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.
Abrogated entry into S phase is a common hallmark of cancer cells. Skp2, a...
Direct Link | 30th July, 2008
| Department of Cell Biology and Physiology, University of Pittsburgh School
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Robust, tunable biological oscillations from interlinked positive and negative feedback loops.
A simple negative feedback loop of interacting genes or proteins has the...
Direct Link | 19th July, 2008
| Department of Chemical and Systems Biology, Stanford University School of
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Protein interactions in the sumoylation cascade: lessons from X-ray structures.
Sumoylation is a multi-step protein modification reaction in which SUMO...
Direct Link | 11th July, 2008
| Department of Neurochemistry, Max-Planck-Institute for Brain Research,
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Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle.
Separation of duplicated centrosomes (spindle-pole bodies or SPBs in...
Direct Link | 9th July, 2008
| Institute of Molecular and Cell Biology, A*STAR (Agency for Science,
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Modulation of the mitotic regulatory network by APC-dependent destruction of the Cdh1 inhibitor Acm1.
The completion of mitosis depends on protein ubiquitination by the...
Direct Link | 4th July, 2008
| Department of Physiology, University of California, San Francisco, San
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Potential role of the ubiquitin-proteasome system in atherosclerosis: aspects of a protein quality disease.
Misfolded or damaged proteins are recognized intracellularly by protein...
Direct Link | 26th June, 2008
| Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905,
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Not-so-pseudo a substrate: Acm1-mediated inhibition of the APC.
In a recent issue of Molecular Cell, Enquist-Newman et al. (2008)...
Direct Link | 20th June, 2008
| Department of Pharmacology and Cancer Biology, Duke University Medical
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