Recent Publications on Uracil Nucleotides: |  |
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
The phosphate, uracil, and ribose moieties of uracil nucleotides were...
Direct Link | 17th July, 2008
| Molecular Recognition Section, Laboratory of Bioorganic Chemistry, NIDDK,
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Stereospecific synthesis of sugar-1-phosphates and their conversion to sugar nucleotides.
As Leloir glycosyltransferases are increasingly being used to prepare...
Direct Link | 3rd June, 2008
| Department of Chemistry, Dalhousie University, Halifax, Nova Scotia,
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UDP is a competitive antagonist at the human P2Y14 receptor.
G protein-coupled P2Y receptors (P2Y-R) are activated by adenine and...
Direct Link | 20th May, 2008
| Department of Pharmacology, University of North Carolina, CB#7365 Mary
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Uracil nucleotides: from metabolic intermediates to neuroprotection and neuroinflammation.
Uracil nucleotides (i.e., UTP and UDP) have been known for years as...
Direct Link | 17th May, 2008
| Laboratory of Molecular and Cellular Pharmacology of Purinergic
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Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes.
We previously showed that the human heart expresses all known P2X and P2Y...
Direct Link | 19th April, 2008
| Laboratory of Molecular and Cellular Pharmacology of Purinergic
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Different patterns of Ca(2+) signals are induced by low compared to high concentrations of P2Y agonists in microglia.
Brain-resident macrophages (microglia) are key cellular elements in the...
Direct Link | 12th April, 2008
| Department of Cell Biology and Neuroscience, Section of Degenerative and
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Structures of the human orotidine-5'-monophosphate decarboxylase support a covalent mechanism and provide a framework for drug design.
UMP synthase (UMPS) catalyzes the last two steps of de novo pyrimidine...
Direct Link | 20th March, 2008
| Department of Molecular Structural Biology, University of Gottingen,
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Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'.
Histone mRNAs are rapidly degraded at the end of S phase or when DNA...
Direct Link | 14th March, 2008
| Department of Biochemistry and Biophysics, University of North Carolina at
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New ways to meet your (3') end oligouridylation as a step on the path to destruction.
Histone mRNAs are rapidly degraded at the end of S phase or when DNA...
Direct Link | 14th March, 2008
| Department of Microbiology, Immunology, and Pathology, Colorado State
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A novel magnetic bead-based assay with high sensitivity and selectivity for analysis of telomerase in exfoliated cells from patients with bladder and colon cancer.
Telomerase activity is elevated in more than 85% of cancer cells and...
Direct Link | 21st February, 2008
| The Ludwig Institute for Cancer Research, Melbourne Tumour Biology Branch,
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Roles for TbDSS-1 in RNA surveillance and decay of maturation by-products from the 12S rRNA locus.
The Trypanosoma brucei exoribonuclease, TbDSS-1, has been implicated in...
Direct Link | 19th February, 2008
| Department of Microbiology and Immunology, Witebsky Center for Microbial
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Liver-specific increase of UTP and UDP-sugar concentrations in rats induced by dietary vitamin B6-deficiency and its relation to complex N-glycan structures of liver membrane-proteins.
This is the first known report on the influence of vitamin B6-deficiency...
Direct Link | 26th January, 2008
| Institut fur Biochemie und Molekularbiologie, Charite -
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Ca2+-dependent ATP release from A549 cells involves synergistic autocrine stimulation by coreleased uridine nucleotides.
Extracellular ATP is a potent surfactant secretagogue but its origin in...
Direct Link | 11th January, 2008
| Centre hospitalier de l'Universite de Montreal - Hotel-Dieu, 3850
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| P2Y receptors: focus on structural, pharmacological and functional aspects in the brain.
| 3rd January, 2008
| Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of
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Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer.
OBJECTIVES: Suicide gene therapy with FCY1 gene, encoding cytosine...
Direct Link | 8th November, 2007
| Department of Medical and Surgical Sciences, University of Padova, Padova,
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