Saturday November 21 2009 | Biotechnology feed | All feeds

BioPortfolio Biotechnology Pharmaceutical Healthcare Medical Life Science Drug Discovery Disease

Urease

Urease is an enzyme that catalyzes the hydrolysis of urea into carbon dioxide and ammonia. The reaction occurs as follows:2CO + H2O → CO2 + 2NH3In 1926 James Sumner showed that urease is a protein. Urease is found in bacteria, yeast and several higher plants.Characteristics:*Active site metal: nickel* Molecular weight: 480 kDa or 545 kDa for Jack Bean Urease .* Optimum pH: 7.4* Optimum Temperature: 60 degrees Celsius* Enzymatic specificity: urea and hydroxyurea* Inhibitors: heavy metalsThe multi-subunit enzyme usually has a 3:3 stoichiometry with a 2-fold symmetric structure . An exceptional urease is found in Helicobacter pylori, which combines four of the regular six subunit enzymes in an overall tetrahedral assembly of 24 subunits . This supra-molecular assembly is thought to confer additional stability for the enzyme in this organism, which functions to produce ammonia in order to neutralise gastric acid. The presence of urease is used in the diagnosis of Helicobacter species. (From the Wikpedia article Urease.)

Download PDF containing detailed information.PDF Version

Image Results

Loading...

Recent Publications on Urease:

Pubmed Logo
Iron deficiency, Helicobacter infection and gastritis.
Despite elegant regulatory mechanisms, iron deficiency anemia (IDA)...
13th November, 2009
Department of Hematology, Shaare Zedek Medical Center, Jerusalem, Israel. Acta Haematol. 2009;122(2-3):97-102. Epub 2009 Nov 10.
DOI Direct Link
Characterization of an O-desmethylangolensin-producing bacterium isolated from human feces.
A bacterium that converted daidzein to O-desmethylangolensin was isolated...
12th November, 2009
Department of Applied Microbiology, Gifu Prefectural Research Institute Arch Microbiol. 2009 Nov 11.
DOI Direct Link
Comparative toxicity of chlorpyrifos and its oxon derivatives to soil microbial activity by combined methods.
The inhibitory effects of the pesticide Chlorpyrifos (CPF) and its oxon...
11th November, 2009
Key Laboratory of Biogeology and Environmental Geology of Chinese Ministry Chemosphere. 2009 Nov 7.
DOI Direct Link
Global gene expression in Staphylococcus aureus following exposure to alcohol.
It was recently shown that, as in yeast, alcohols selectively increase the...
11th November, 2009
Department of Human Microbiology, Sackler School of Medicine, Tel Aviv Microb Pathog. 2009 Nov 6.
DOI Direct Link
Development of a Recombinant Ureolytic Lactococcus Lactis for Urea Removal.
Abstract Kidney failure is a common disease with high frequency....
11th November, 2009
Key Laboratory of Bioactive Materials, Ministry of Education, College of Artif Cells Blood Substit Immobil Biotechnol. 2009 Nov 10.

View more research publications.

Press Releases About Urease:

BioPortfolio Logo
Catachem Announces FDA Approval of the Blood Urea Nitrogen (BUN) In-Vitro 1st January, 1970 Catachem
Catachem Announces FDA Approval of the Blood Urea Nitrogen (BUN) In-Vitro Diagnostic (IVD) Chemistry Reagent Kit Bridgeport, Connecticut, USA (June 7, 1989)…. Catachem, Inc. (Private)

Urease Clinical Trials:

Clinical Trials Logo
Feasibility Study of Phototherapy System to Treat H Pylori

Urease Patents:

USPTO Logo
US Patent No.Title
7592003 Regulation of toll-like receptors on stem cells
7598031 Method for the detection of gene transcripts in blood and uses thereof
7598050 Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a chloride intracellular channel 1 protein
7598208 Filter cake degradation compositions and methods of use in subterranean operations
7598273 Inhibitors of the gastric H.sup.+, K.sup.+-ATPase with enhanced therapeutic properties

View more patents.

BioPortfolio Ltd. offers e-mail and postal lists for Urease scientists - we have details of around 688 individuals working on Urease .


This page has been viewed 884 times
Recent Search Terms used to find this page: UREASE | optimal pH of urease | optimal pH of urease | enzyme urease optimum temperature | urease optimum temperature | urease | how would you find the optimum temperature of Urease | urease | h pylori urease optimum ph | .
Browse BioPortfolio's InDepth service - alphabetically: A B C D E F G H I J K L M N O P Q R S T U V W X Y Z or by Most Publications, recently searched for, or most viewed.

Search for Urease across BioPortfolio, or for Urease Research Reports
Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH. Thumbshots from Thumbshots.org

 

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

All rights reserved. All other trademarks recognized.
Copyright 1997-2009 - BioPortfolio Limited.