Recent Publications on Uridine Diphosphate Glucuronic Acid: |  |
Mapping the UDP-glucuronic acid binding site in UDP-glucuronosyltransferase-1A10 by homology-based modeling: confirmation with biochemical evidence.
The UDP-glucuronosyltransferase (UGT) isozyme system is critical for...
Direct Link | 2nd August, 2008
| Heritable Disorders Branch, National Institute of Child Health and Human
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Glucuronidation of polychlorinated biphenylols and UDP-glucuronic acid concentrations in channel catfish liver and intestine.
Polychlorinated biphenylols (OH-PCBs) are potentially toxic...
Direct Link | 24th June, 2008
| Department of Medicinal Chemistry, University of Florida, PO Box 100485,
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The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis.
All UDP-glucuronosyltransferase enzymes (UGTs) share a common cofactor,...
Direct Link | 7th May, 2008
| Department of Biochemistry and Molecular Biology, University of Arkansas
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| The prediction of the hepatic clearance of tanshinone IIA in rat liver subcellular fractions: accuracy improvement.
| 25th April, 2008
| Key Lab of Drug Metabolism and Pharmacokinetics, China Pharmaceutical
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Flagellin glycosylation in Pseudomonas aeruginosa PAK requires the O-antigen biosynthesis enzyme WbpO.
Pseudomonas aeruginosa PAK (serotype O6) produces a single polar,...
Direct Link | 1st April, 2008
| Department of Molecular and Cellular Biology, University of Guelph,
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Activators of the farnesoid X receptor negatively regulate androgen glucuronidation in human prostate cancer LNCAP cells.
Androgens are major regulators of prostate cell growth and physiology. In...
Direct Link | 18th March, 2008
| Molecular Endocrinology and Oncology Research Center, CHUL Research
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Characterization of 1'-hydroxymidazolam glucuronidation in human liver microsomes.
Midazolam is a potent benzodiazepine derivative with sedative, hypnotic,...
Direct Link | 22nd February, 2008
| Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ
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In vitro metabolism of KBH-A40, a novel delta-lactam-based histone deacetylase (HDAC) inhibitor, in human liver microsomes and serum.
1. The metabolism of KBH-A40, a novel delta-lactam-based histone...
Direct Link | 16th February, 2008
| Bio-Evaluation Center, KRIBB, Cungbuk, Korea.
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Interaction between valproic acid and carbapenem antibiotics.
The serum concentration of valproic acid (VPA) in epilepsy patients...
Direct Link | 21st December, 2007
| Graduate School of Pharmaceutical Sciences, Nagoya City University,
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Prediction of metabolic clearance of bisphenol A (4,4 '-dihydroxy-2,2-diphenylpropane) using cryopreserved human hepatocytes.
This study investigated the kinetics of glucuronidation of bisphenol A...
Direct Link | 13th December, 2007
| Department of Pharmacology, College of Medicine, The University of
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Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid.
Gemfibrozil coadministration generally results in plasma statin area under...
Direct Link | 6th November, 2007
| Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global
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Variety of nucleotide sugar transporters with respect to the interaction with nucleoside mono- and diphosphates.
Nucleotide sugar transporters have long been assumed to be antiporters...
Direct Link | 12th October, 2007
| Stem Cell Project, Tokyo Metropolitan Institute of Medical Science, Tokyo
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Comparative analysis of two UDP-glucose dehydrogenases in Pseudomonas aeruginosa PAO1.
UDP-glucose dehydrogenase (UGDH) catalyzes a two-step NAD(+)-dependent...
Direct Link | 26th September, 2007
| Institute of Molecular Medicine, National Tsing Hua University, Hsin Chu
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Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-na phthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action.
Methyl...
Direct Link | 21st September, 2007
| Developmental Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
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| Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine.
| 8th June, 2007
| Drug Metabolism and Toxicology, Division of Pharmaceutical Sciences,
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