Vaccinia

Vaccinia virus is a large, complex, enveloped virus belonging to the poxvirus family. It has a linear, double-stranded DNA genome approximately 190 kbp in length, and which encodes for approximately 250 genes. The dimensions of the virion are roughly 360 × 270 × 250 nm. Vaccinia virus is well-known for its role as a vaccine that eradicated the smallpox disease, making it the first human disease to be successfully eradicated by mankind. This endeavour was carried out by the World Health Organization under the Smallpox Eradication Program. Post eradication of smallpox, scientists study Vaccinia virus to use as a tool for delivering genes into biological tissues . Moreover, due to recent concerns about smallpox resurfacing as a possible agent for bioterrorism, scientists have renewed their interests in studying Vaccinia virus. (From the Wikpedia article Vaccinia.)

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Recent Publications on Vaccinia:
Virion disruption by ozone-mediated reactive oxygen species. It is well documented in the scientific literature that ozone-oxygen...	5th July, 2008	Department of Microbiology and Molecular Biology, Brigham Young	J Virol Methods. 2008 Jun 30;. DOI Direct Link
Vaccinia Virus L1 Protein is Required for Cell Entry and Membrane Fusion. Genetic and biochemical studies have provided evidence for an entry/fusion...	4th July, 2008	Laboratory of Viral Diseases, National Institute of Allergy and Infectious	J Virol. 2008 Jul 2;. DOI Direct Link
A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. BACKGROUND: TG4010 is a recombinant viral vector expressing both the...	3rd July, 2008	Regional Center for Lung Disease, Wielkopolskie Centrum, Poznan, Poland.	J Thorac Oncol. 2008 Jul;3(7):735-44. DOI Direct Link
Vaccinia Virus Blocks Stat1-Dependent and Stat1-Independent Gene Expression Induced by Type I and Type II Interferons. Blocking the function of Stat (signal transducer and activator of...	3rd July, 2008	Department of Pediatrics, Herman B. Wells Center for Pediatric Research,	J Interferon Cytokine Res. 2008 Jun;28(6):367-80. DOI Direct Link
Regulation of maturation and activating potential in CD8(+) versus CD8(-) dendritic cells following in vivo infection with vaccinia virus. DC maturation is known to be a necessary step in the generation of an...	1st July, 2008	Department of Microbiology and Immunology, Room 5053, Hanes Building, Wake	Virology. 2008 Jun 27;. DOI Direct Link
→View more research publications.

BioNews Results for Vaccinia:
Oxford BioMedica rejects lawsuit brought by Bavarian Nordic	Pharma Times:  Jul 3 2008 1:57PM Matching: vaccinia
TechMARK movers: Total Systems posts profit	Digital Look:  Jul 1 2008 4:39PM Matching: vaccinia
TechMARK movers: Total Systems posts profit	City A.M.:  Jul 1 2008 3:59PM Matching: vaccinia
Oxford Biomedica gets infringement suit from Danish firm	Digital Look:  Jul 1 2008 1:02PM Matching: vaccinia
Oxford Biomedica gets infringement suit from Danish firm	ShareCast:  Jul 1 2008 12:46PM Matching: vaccinia
Promote your company here: BioNewsCast - Press Release Distribution	→View more news.

Vaccinia Clinical Trials:
Vaccine Therapy With or Without Sargramostim in Treating Patients With Cancer	Unspecified Adult Solid Tumor, Protocol Specific
Vaccine Therapy in Treating Patients With Metastatic Melanoma	Melanoma (Skin)
Vaccine Therapy in Treating Patients With Metastatic Melanoma	Melanoma (Skin)
Sequential Vaccinations in Prostate Cancer Patients	Prostatic Neoplasms
SIGA-246 to Treat Smallpox	Vaccinia Intervention: Drug: Vaccine: SIGA-246
→View more trials.

Vaccinia Patents:
US Patent No.	Title
7388093	Gene for identifying individuals with familial dysautonomia
7390871	Tumor antigen based on products of the tumor suppressor gene WT1
7390879	Secreted and transmembrane polypeptides and nucleic acids encoding the same
7390880	Soluble interleukin-1 receptor accessory molecule
7390888	Dendritic cell potentiation
→View more patents.

Companies working in the area of Vaccinia from Bioportfolio's Biocorporate database :
Company Name
Transgene TRANSGENE is a leading integrated gene therapy company, dedicated to the discovery and development of gene delivery technologies and gene therapy products for the treatment of acquired and inherited... www.transgene.fr/        View full profile
BioDETECT BioDETECT's compact, portable flow cytometerers are today used to assists a.o.: wineries and breweries to analyse and detect yeast, water works to verify water filtration processes, pharmaceutical... www.biodetect.biz/        View full profile
Omrix Biopharmaceuticals We aim to develop novel technologies to provide safer and more effective options to patients in areas with substantial unmet medical needs, particularly in the areas of biosurgical and passive... www.omrix.com/index.asp        View full profile
→View more Vaccinia related companies.

BioPortfolio Ltd. offers e-mail and postal lists for Vaccinia scientists - we have details of around 1200 individuals working on Vaccinia .

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