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Valine-TRNA Ligase

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Recent Publications on Valine-TRNA Ligase:

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Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutation.
Phenotypic diversity associated with pathogenic mutations of the human...
14th June, 2008
Mitochondrial Research Group, Institute of Neuroscience, Medical School, Nucleic Acids Res. 2008 May;36(9):3065-74. Epub 2008 Apr 8.
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A present-day aminoacyl-tRNA synthetase with ancestral editing properties.
Leucyl-, isoleucyl-, and valyl-tRNA synthetases form a subgroup of related...
31st January, 2007
State Key Laboratory of Molecular Biology, Institute of Biochemistry and RNA. 2007 Jan;13(1):15-21. Epub 2006 Nov 9.
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Global effects of mistranslation from an editing defect in mammalian cells.
Aminoacyl-tRNA synthetases prevent mistranslation, or genetic code...
23rd December, 2006
Department of Molecular Biology, The Skaggs Institute for Chemical Chem Biol. 2006 Oct;13(10):1091-100.
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Structural basis for substrate recognition by the editing domain of isoleucyl-tRNA synthetase.
In isoleucyl-tRNA synthetase (IleRS), the "editing" domain contributes to...
11th August, 2006
Department of Biophysics and Biochemistry, Graduate School of Science, J Mol Biol. 2006 Jun 16;359(4):901-12. Epub 2006 Apr 25.
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Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit.
Eukaryotic valyl-tRNA synthetase (ValRS) and the heavy form of elongation...
24th December, 2005
Department of Biochemistry, The University of Mississippi Medical Center, FEBS Lett. 2005 Nov 7;579(27):6049-54. Epub 2005 Oct 6.
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Valine-TRNA Ligase Patents:

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US Patent No.Title
7365178 Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
6551795 Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics
6902887 Methods for monitoring multiple gene expression
7018794 Methods for monitoring multiple gene expression
7052913 Matrices for drug delivery and methods for making and using the same

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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