Wakefulness

Wakefulness refers to the state of being awake and is the behavioral manifestation of the metabolic state of catabolism. It is the daily recurring period in an organism's life during which consciousness, awareness and all behaviors necessary for survival, i.e., success in , are conducted. Being awake is the opposite of being asleep a behavioral manifestation of the daily recurring metabolic state of anabolism. Animals can eat and run, fly, swim or walk while awake; humans can also talk, listen, write, read, and productively think and work in the awake state. It is self-evident that the behaviors which take place while an organism is awake are necessary, complex, interesting and diverse. As sleep is biologically necessary, an excess of time spent awake is considered sleep deprivation, and there are serious physiological and psychological consequences both for individual stretches of wakefulness and serial preference for wakeful activity rather than sleep. (From the Wikpedia article Wakefulness.)

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Recent Publications on Wakefulness:
State-Dependent Versus Central Motor Effects of Ethanol on Breathing. Ethanol is one of the most widely used drugs in western society and...	21st November, 2009	University of Toronto.	J Appl Physiol. 2009 Nov 19. DOI Direct Link
A Mathematical Model of Homeostatic Regulation of Sleep-Wake Cycles by Hypocretin/Orexin. We introduce a physiology-based mathematical model of sleep-wake cycles,...	21st November, 2009	Institute of Physiology, Philipps University of Marburg, Marburg, Germany.	J Biol Rhythms. 2009 Dec;24(6):523-535. DOI Direct Link
Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse Models. To determine the respective role played by orexin/hypocretin and histamine...	20th November, 2009	Inserm-U628, Integrated Physiology of Brain Arousal Systems, IFR19, 69373	J Neurosci. 2009 Nov 18;29(46):14423-14438. DOI Direct Link
Orexins Excite Neurons of the Rat Cerebellar Nucleus Interpositus Via Orexin 2 Receptors In Vitro. Orexins are newfound hypothalamic neuropeptides implicated in the...	19th November, 2009	Department of Biological Science and Technology and State Key Laboratory	Cerebellum. 2009 Nov 19. DOI Direct Link
Modafinil in the treatment of excessive sleepiness. The wake-promoting agent modafinil is approved for the treatment of...	19th November, 2009	INTEGRIS Sleep Disorders Center and University of Oklahoma Health Sciences	Drug Des Devel Ther. 2009 Feb 6;2:71-85.
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Wakefulness Patents:
US Patent No.	Title
7524864	Methods of treating sleep disorders
7553964	Cyclobutyl amine derivatives
7556938	Nucleic acids encoding potassium channel interactors
7557117	4-oxoimidazolidine-2-spiropiperidine derivatives
7560570	Inhibitors of fatty acid amide hydrolase
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Companies working in the area of Wakefulness from Bioportfolio's Biocorporate database :
Company Name
The Center for Sleep & Wake Disorders The Center for Sleep & Wake Disorders is a full service sleep center caring for patients with all disorders of sleep and wakefulness. Patients enjoy the advantages of an expertly trained staff, the... www.sleepdoc.com/        View full profile

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