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Withanolides

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Recent Publications on Withanolides:

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Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection.
A reversed-phase HPLC method for the simultaneous analysis of nine...
13th May, 2008
Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Phytochem Anal. 2008 Mar;19(2):148-54.
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Withangulatin I, a new cytotoxic withanolide from Physalis angulata.
A new withanolide, withangulatin I (2), was isolated from the whole plant...
20th March, 2008
Department of Applied Chemistry, Chia-Nan University of Pharmacy and Chem Pharm Bull (Tokyo). 2008 Feb;56(2):234-6.
Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera).
Ashwagandha (Withania somnifera Dunal., Solanaceae) is one of the most...
4th March, 2008
Central Institute of Medicinal and Aromatic Plants (CSIR), PO CIMAP, Physiol Plant. 2008 Jun;133(2):278-87. Epub 2008 Feb 26.
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Withania somnifera inhibits NF-kappaB and AP-1 transcription factors in human peripheral blood and synovial fluid mononuclear cells.
Withania somnifera (WS) is an important herb with known antiinflammatory...
1st February, 2008
Department of Immunology, Sanjay Gandhi Post-Graduate Institute of Medical Phytother Res. 2007 Oct;21(10):905-13.
DOI Direct Link
Withanolides from Jaborosa laciniata.
Six new trechonolide type withanolides (compounds 1- 6), together with...
18th December, 2007
Departamento de Quimica Organica and UMYMFOR (CONICET-FCEN), Facultad de J Nat Prod. 2007 Oct;70(10):1644-6. Epub 2007 Sep 21.
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Withanolides Patents:

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US Patent No.Title
6822102 Dihydrobenzopyrans, dihydrobenzothiopyrans, and tetrahydroquinolines for the treatment of COX-2 mediated disorders
6955873 Diagnosis and treatment system for reward deficiency syndrome (RDS) and related behaviors
6995162 Substituted alkylamine derivatives and methods of use
6998394 Process for isolating physalins from plants and pharmaceutical compositions containing physalins
7005450 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors

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Wikipedia excerpt, where present, licenced under the GNU Free Documentation License. Resources from the NCBI applied. Selected MeSH subject headings created and maintained by the US NLM are used in conjunction with additional keywords. 2006-2008 MeSH.
 

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