Zalcitabine

Zalcitabine , also called dideoxycytidine, is a nucleoside analog reverse transcriptase inhibitor sold under the trade name Hivid®. The recommended dosage is 0.750 mg every 8 hours, as part of a combination regimen.Zalcitabine appears less potent than some other nucleoside RTIs, has an inconvenient three-times daily frequency and is associated with serious adverse events. For these reasons it is now rarely used to treat human immunodeficiency virus . (From the Wikpedia article Zalcitabine.)

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Recent Publications on Zalcitabine:
The history of antiretrovirals: key discoveries over the past 25 years. Within 25 years after zidovudine (3'-azido-2',3'-dideoxythymidine, AZT)...	7th November, 2009	Department of Microbiology and Immunology, Rega Institute for Medical	Rev Med Virol. 2009 Sep;19(5):287-99. DOI Direct Link
Clinical evaluation of local ocular toxicity in candidate anti-adenoviral agents in vivo. BACKGROUND: Adenovirus causes ophthalmological nosocomial infections....	14th October, 2009	Department of Ophthalmology, Fukuoka University School of Medicine,	Ophthalmologica. 2009;223(4):233-8. Epub 2009 Mar 5. DOI Direct Link
Mitochondrial DNA depletion and respiratory chain activity in primary human subcutaneous adipocytes treated with nucleoside-analogue reverse transcriptase inhibitors. Objective: Mitochondrial (mt) dysfunction as a consequence of mtDNA...	7th October, 2009	Clinic for Immunology and Rheumatology, Clinic for Paediatric Nephrology,	Antimicrob Agents Chemother. 2009 Oct 5. DOI Direct Link
Freeze-drying of squalenoylated nucleoside analogue nanoparticles. Nucleoside analogues are potent anticancer or antiviral agents that...	29th September, 2009	Universite Paris-Sud XI, Faculte de Pharmacie, UMR CNRS 8612, IFR 141,	Int J Pharm. 2009 Nov 3;381(2):140-5. Epub 2009 Apr 11. DOI Direct Link
Assessment of mitochondrial toxicity by analysis of mitochondrial protein expression in mononuclear cells. BACKGROUND: Real-time PCR has quantified decreased mitochondrial DNA...	21st July, 2009	Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research	Cytometry B Clin Cytom. 2009 May;76(3):181-90. DOI Direct Link
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Zalcitabine Patents:
US Patent No.	Title
7576097	Tropane derivatives useful in therapy
7589204	Indane compounds as CCR5 antagonists
7589207	Cyclohexyl compounds as CCR5 antagonists
7589233	L-Threonine derivatives of high therapeutic index
7592010	Albumin fusion proteins
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BioPortfolio Ltd. offers e-mail and postal lists for Zalcitabine scientists - we have details of around 129 individuals working on Zalcitabine .