Recent Publications on p21-Activated Kinases: |  |
PAK signalling in neuronal physiology.
Group I p21-activated kinases are a family of key effectors of Rac1 and...
Direct Link | 28th November, 2008
| CNRS, Institut de Neurobiologie Alfred Fessard - FRC2118, Laboratoire de
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Schizosaccharomyces pombe Pak-related protein, Pak1p/Orb2p, phosphorylates myosin regulatory light chain to inhibit cytokinesis.
p21-activated kinases (Paks) have been identified in a variety of...
Direct Link | 26th November, 2008
| Cell Division Laboratory, Temasek Life Sciences Laboratory, and
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Lidocaine inhibits NIH-3T3 cell multiplication by increasing the expression of cyclin-dependent kinase inhibitor 1A (p21).
BACKGROUND: We explored molecular mechanisms by which lidocaine inhibits...
Direct Link | 19th November, 2008
| Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory
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Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids.
We previously reported that the barrier-protective effects of oxidized...
Direct Link | 19th November, 2008
| Dept. of Medicine, University of Chicago, Chicago, IL 60637, USA.
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Targeted disruption of the Pak5 and Pak6 genes in mice leads to deficits in learning and locomotion.
PAK6 is a member of the group B family of PAK serine/threonine kinases,...
Direct Link | 19th November, 2008
| Susan Lehman Cullman Laboratory for Cancer Research, Department of
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Scrib regulates PAK activity during the cell migration process.
Genetic studies have highlighted the key role of Scrib in the development...
Direct Link | 18th November, 2008
| Inserm, U891, Centre de Recherche en Cancerologie de Marseille,
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MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions.
MicroRNAs are noncoding RNAs that inhibit the expression of their targets...
Direct Link | 8th November, 2008
| Department of Molecular and Cellular Oncology, The University of Texas MD
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Biochemical and structural characterization of the Pak1-LC8 interaction.
Pak1 (p21-activated kinase-1) and the dynein light chain, LC8, are...
Direct Link | 5th November, 2008
| Department of Biochemistry and Molecular Biology, Thomas Jefferson
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Rac regulates the interaction of fascin with protein kinase C in cell migration.
Fascin is an actin-bundling protein that is low or absent in normal...
Direct Link | 31st October, 2008
| Randall Division of Cell and Molecular Biophysics, King's College London,
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Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.
BACKGROUND: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is...
Direct Link | 28th October, 2008
| Department of Biological Sciences, University of Cyprus, Cyprus.
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PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival.
As activation of the Ras/Raf/MEK/ERK pathway is a critical component of...
Direct Link | 17th October, 2008
| Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester,
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Separase cooperates with Zds1 and Zds2 to activate Cdc14 phosphatase in early anaphase.
Completion of mitotic exit and cytokinesis requires the inactivation of...
Direct Link | 10th October, 2008
| Chromosome Segregation Laboratory, Cancer Research UK London Research
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p21-activated kinase signaling regulates oxidant-dependent NF-kappa B activation by flow.
Disturbed blood flow induces inflammatory gene expression in endothelial...
Direct Link | 9th October, 2008
| Cardiovascular Research Center, University of Virginia, Charlottesville,
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Validation of the p21-activated kinases as targets for inhibition in neurofibromatosis type 2.
Neurofibromatosis type 2 (NF2) is a dominantly inherited cancer disorder...
Direct Link | 3rd October, 2008
| Molecular and Cellular Oncogenesis Program, The Wistar Institute,
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The potassium ion channel opener NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
Diverse types of voltage-gated potassium (K+) channels have been shown to...
Direct Link | 19th September, 2008
| Cancer Biology Research Center, Tongji Hospital, Tongji Medical College,
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